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International Urogynecology Journal

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01-07-2010 | Original Article

Rectovaginal fistula model in the New Zealand white rabbit

Authors: Matthew J. Aungst, John R. Fischer, Michael R. Bonhage, Todd S. Albright, Kathleen A. Noel, Johnnie Wright

Published in: International Urogynecology Journal | Issue 7/2010

Abstract

Introduction and hypothesis

The purpose of this study was to create an animal model to study rectovaginal fistula repair.

Methods

Fourteen New Zealand white rabbits underwent surgical creation of a rectovaginal fistula. The technique was developed with a pilot study conducted on the first two animals, then standardized and performed on the remaining 12 rabbits. The standardized technique included making a defect in the rectovaginal septum using a 3-mm skin punch then splinting the defect with 6-mm tubing for 2 weeks.

Results

Using the standardized technique, a fistula was successfully created in all 12 rabbits ranging from 1 to 5 mm (mean = 2.8 mm, SD = 1.1). A 95% tolerance interval was calculated for the model and predicted that a successful fistula can be created ranging from 0.3 to 5.2 mm in 85% of attempts with the model.

Conclusion

The New Zealand white rabbit is a promising animal model to study rectovaginal fistula repair.

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Title: Rectovaginal fistula model in the New Zealand white rabbit
Authors: Matthew J. Aungst
John R. Fischer
Michael R. Bonhage
Todd S. Albright
Kathleen A. Noel
Johnnie Wright
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 7/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1118-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Rectovaginal fistula model in the New Zealand white rabbit

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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