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01-01-2010 | Original Article

Effects of soy isoflavones on the uterus and urethra of ovariectomized rats

Authors: Elaine Travaglia Santos, Maria Dione Dutra Sampaio, Paulo Roberto Cecon, Manuel de Jesus Simões, Marair Gracio Ferreira Sartori, Manoel João Batista Castello Girão

Published in: International Urogynecology Journal | Issue 1/2010

Abstract

Objective

To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.

Methods

Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 μg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).

Results

Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.

Conclusions

Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.

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Title: Effects of soy isoflavones on the uterus and urethra of ovariectomized rats
Authors: Elaine Travaglia Santos
Maria Dione Dutra Sampaio
Paulo Roberto Cecon
Manuel de Jesus Simões
Marair Gracio Ferreira Sartori
Manoel João Batista Castello Girão
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 1/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0995-6

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Springer Medicine

Effects of soy isoflavones on the uterus and urethra of ovariectomized rats

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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