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International Urogynecology Journal

Published in:

01-04-2009 | Original Article

Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft

Authors: Yves Ozog, Maja L. Konstantinovic, Sofie Verschueren, Federico Spelzini, Dirk De Ridder, Jan Deprest

Published in: International Urogynecology Journal | Issue 4/2009

Abstract

Introduction and hypothesis

To assess the biomechanical properties of full-thickness abdominal wall defects, either using Native tissues, with or without Overlay, and by substitution of the Defect by small intestinal submucosa mesh.

Methods

Seventy-two rats were divided into three groups according to repair method (Native, Overlay or Defect). At 7, 14, 30, and 90 days, six rats were sacrificed to measure tensile strength, collagen ingrowth, and host response.

Results

Explants had comparable strength at 30 days, the majority rupturing at the interface. Afterwards, the Native group was more resistant than both small intestine submucosa (SIS) groups with a more organized fibrotic scar on histology at 90 days.

Conclusions

SIS augmentation of native tissue repair does not increase strength. Replacement of abdominal wall by SIS is equally strong when compared to the SIS-augmented group; however, materials preferably rupture at the site of the implant itself.

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Title: Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft
Authors: Yves Ozog
Maja L. Konstantinovic
Sofie Verschueren
Federico Spelzini
Dirk De Ridder
Jan Deprest
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 4/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-008-0793-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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