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Published in: Knee Surgery, Sports Traumatology, Arthroscopy 5/2017

01-05-2017 | Knee

The natural history of donor hamstrings unit after anterior cruciate ligament reconstruction: a prospective MRI scan assessment

Authors: Ioannis Tsifountoudis, Ilias Bisbinas, Ioannis Kalaitzoglou, George Markopoulos, Aphrodite Haritandi, Athanasios Dimitriadis, Stergios Papastergiou

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 5/2017

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Abstract

Purpose

The aim of this prospective study was to assess the natural history of the donor hamstrings, compared to the contralateral knee and thigh.

Methods

In 47 patients who had ACL reconstruction (hamstrings technique), bilateral knees and thighs were investigated using MRI scans, up to 2 years post-operatively.

Results

Tendon regeneration below the knee joint line of the semitendinosus occurred in 30/47 (64 %) patients and of the gracilis tendon in 17/47 (36 %) patients. Insertion of both tendons at the “pes anserinus”, with normal anatomic relations, was observed in 5/47 (11 %) patients. Semitendinosus and gracilis donor muscles were found retracted in 41/47 (87 %) patients. In 25/47 (53 %) patients, there was evidence of fatty infiltration of the semitendinosus muscle. All (47/47) (100 %) patients showed semitendinosus muscle atrophy and 41/47 (87 %) patients showed gracilis muscle atrophy, compared to the contralateral limb. High signal intensity on STIR images was observed in the semitendinosus in 22/47 (46 %) patients and in the gracilis muscle in 30/47 (64 %) patients, on MRI examination performed up to 24 months post-operatively.

Conclusions

The “regenerated” hamstrings tendons most commonly do not regenerate fully anatomically, so they should not be considered as a first choice for re-harvesting in revision ACL reconstruction. The “donor hamstrings muscles” are found to be shorter, contracted, thinner and with a long-term abnormal MRI signal, features which are considered to be related to reduced muscle performance (knee flexion and internal rotation) post-operatively.

Level of evidence

II.
Literature
1.
go back to reference Ahlen M, Liden M (2011) A comparison of the clinical outcome after anterior cruciate ligament reconstruction using hamstring tendon autograft with special emphasis on the timing of the reconstruction. Knee Surg Sports Traumatol Arthrosc 19:488–494CrossRefPubMed Ahlen M, Liden M (2011) A comparison of the clinical outcome after anterior cruciate ligament reconstruction using hamstring tendon autograft with special emphasis on the timing of the reconstruction. Knee Surg Sports Traumatol Arthrosc 19:488–494CrossRefPubMed
2.
go back to reference Ahlen M, Liden M, Bovaller A, Sernert N, Kartus J (2012) Bilateral magnetic resonance imaging and functional assessment of the semitendinosus and gracilis tendons a minimum of 6 years after ipsilateral harvest for anterior cruciate ligament reconstruction. Am J Sports Med 40:1735–1741CrossRefPubMed Ahlen M, Liden M, Bovaller A, Sernert N, Kartus J (2012) Bilateral magnetic resonance imaging and functional assessment of the semitendinosus and gracilis tendons a minimum of 6 years after ipsilateral harvest for anterior cruciate ligament reconstruction. Am J Sports Med 40:1735–1741CrossRefPubMed
3.
go back to reference Ardern CL, Webster KE, Taylor NF, Feller JA (2010) Hamstrings strength recovery after hamstring tendon harvest for anterior cruciate ligament reconstruction: a comparison between graft types. Arthroscopy 26:462–469CrossRefPubMed Ardern CL, Webster KE, Taylor NF, Feller JA (2010) Hamstrings strength recovery after hamstring tendon harvest for anterior cruciate ligament reconstruction: a comparison between graft types. Arthroscopy 26:462–469CrossRefPubMed
4.
go back to reference Barenius B, Webster WK, McClelland J, Feller J (2013) Hamstring tendon anterior cruciate ligament reconstruction: does gracilis tendon harvest matter? Int Orthop 37:207–212CrossRefPubMed Barenius B, Webster WK, McClelland J, Feller J (2013) Hamstring tendon anterior cruciate ligament reconstruction: does gracilis tendon harvest matter? Int Orthop 37:207–212CrossRefPubMed
5.
go back to reference Burks RT, Crim J, Fink BP, Boylan DM, Greis PE (2005) The effects of semitendinosus and gracilis harvest in anterior cruciate ligament reconstruction. Arthroscopy 21:1177–1185CrossRefPubMed Burks RT, Crim J, Fink BP, Boylan DM, Greis PE (2005) The effects of semitendinosus and gracilis harvest in anterior cruciate ligament reconstruction. Arthroscopy 21:1177–1185CrossRefPubMed
6.
go back to reference Carofino B, Fulkerson J (2005) Medial hamstring tendon regeneration following harvest for anterior cruciate ligament reconstruction: fact, myth, and clinical implication. Arthroscopy 21:1257–1265CrossRefPubMed Carofino B, Fulkerson J (2005) Medial hamstring tendon regeneration following harvest for anterior cruciate ligament reconstruction: fact, myth, and clinical implication. Arthroscopy 21:1257–1265CrossRefPubMed
7.
go back to reference Conte EJ, Hyatt AE, Gatt CJ Jr, Dhawan A (2014) Hamstring autograft size can be predicted and is a potential risk factor for anterior cruciate ligament reconstruction failure. Arthroscopy 30:882–890CrossRefPubMed Conte EJ, Hyatt AE, Gatt CJ Jr, Dhawan A (2014) Hamstring autograft size can be predicted and is a potential risk factor for anterior cruciate ligament reconstruction failure. Arthroscopy 30:882–890CrossRefPubMed
8.
go back to reference Conteduca F, Morelli F, Masi V (2002) Regeneration of the semitendinosus tendon after its use in anterior cruciate ligament reconstruction: a histologic study of three cases. Am J Sports Med 30:204–207PubMed Conteduca F, Morelli F, Masi V (2002) Regeneration of the semitendinosus tendon after its use in anterior cruciate ligament reconstruction: a histologic study of three cases. Am J Sports Med 30:204–207PubMed
9.
go back to reference Cross MJ, Roger G, Kujuwa P, Anderson IF (1992) Regeneration of the semitendinosus and gracilis tendons following their transection for repair of the anterior cruciate ligament. Am J Sports Med 20:221–223CrossRefPubMed Cross MJ, Roger G, Kujuwa P, Anderson IF (1992) Regeneration of the semitendinosus and gracilis tendons following their transection for repair of the anterior cruciate ligament. Am J Sports Med 20:221–223CrossRefPubMed
10.
go back to reference Eriksson K, Hamberg P, Jansson E, Larsson H, Shalabi A, Wredmark T (2001) Semitendinosus muscle in anterior cruciate ligament surgery: morphology and function. Arthroscopy 17:808–817CrossRefPubMed Eriksson K, Hamberg P, Jansson E, Larsson H, Shalabi A, Wredmark T (2001) Semitendinosus muscle in anterior cruciate ligament surgery: morphology and function. Arthroscopy 17:808–817CrossRefPubMed
11.
go back to reference Eriksson K, Kindblom LG, Hamberg P, Larsson H, Wredmark T (2001) The semitendinosus tendon regenerates after resection: a morphologic and MRI analysis in 6 patients after resection for anterior cruciate ligament reconstruction. Acta Orthop Scand 72:379–384CrossRefPubMed Eriksson K, Kindblom LG, Hamberg P, Larsson H, Wredmark T (2001) The semitendinosus tendon regenerates after resection: a morphologic and MRI analysis in 6 patients after resection for anterior cruciate ligament reconstruction. Acta Orthop Scand 72:379–384CrossRefPubMed
12.
go back to reference Eriksson K, Larsson H, Wredmark T, Hamberg P (1999) Semitendinosus tendon regeneration after harvesting for ACL reconstruction. A prospective MRI study. Knee Surg Sports Traumatol Arthrosc 7:220–225CrossRefPubMed Eriksson K, Larsson H, Wredmark T, Hamberg P (1999) Semitendinosus tendon regeneration after harvesting for ACL reconstruction. A prospective MRI study. Knee Surg Sports Traumatol Arthrosc 7:220–225CrossRefPubMed
13.
go back to reference Gill SS, Turner MA, Battaglia TC, Leis HT, Balian G, Miller MD (2004) Semitendinosus regrowth: biochemical, ultrastructural, and physiological characterization of the regenerate tendon. Am J Sports Med 32:1173–1181CrossRefPubMed Gill SS, Turner MA, Battaglia TC, Leis HT, Balian G, Miller MD (2004) Semitendinosus regrowth: biochemical, ultrastructural, and physiological characterization of the regenerate tendon. Am J Sports Med 32:1173–1181CrossRefPubMed
14.
go back to reference Hioki S, Fukubayashi T, Ikeda K, Niitsu M, Ochiai N (2003) Effect of harvesting the hamstring tendons for anterior cruciate ligament reconstruction on the morphology and movement of the hamstring muscles: a novel MRI technique. Knee Surg Sports Traumatol Arthrosc 11:223–227CrossRefPubMed Hioki S, Fukubayashi T, Ikeda K, Niitsu M, Ochiai N (2003) Effect of harvesting the hamstring tendons for anterior cruciate ligament reconstruction on the morphology and movement of the hamstring muscles: a novel MRI technique. Knee Surg Sports Traumatol Arthrosc 11:223–227CrossRefPubMed
15.
go back to reference Janssen RP, du Mee AW, van Valkenburg J, Sala HA, Tseng CM (2013) Anterior cruciate ligament reconstruction with 4-strand hamstring autograft and accelerated rehabilitation: a 10-year prospective study on clinical results, knee osteoarthritis and its predictors. Κnee Surg Sports Traumatol Arthrosc 21:1977–1988CrossRef Janssen RP, du Mee AW, van Valkenburg J, Sala HA, Tseng CM (2013) Anterior cruciate ligament reconstruction with 4-strand hamstring autograft and accelerated rehabilitation: a 10-year prospective study on clinical results, knee osteoarthritis and its predictors. Κnee Surg Sports Traumatol Arthrosc 21:1977–1988CrossRef
16.
go back to reference Janssen RP, van der Velden MJ, Pasmans HL, Sala HA (2013) Regeneration of hamstring tendons after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 21:898–905CrossRefPubMed Janssen RP, van der Velden MJ, Pasmans HL, Sala HA (2013) Regeneration of hamstring tendons after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 21:898–905CrossRefPubMed
17.
go back to reference Kamath S, Venkatanarasimha N, Walsh MA, Hughes PM (2008) MRI appearance of muscle denervation. Skelet Radiol 37:397–404CrossRef Kamath S, Venkatanarasimha N, Walsh MA, Hughes PM (2008) MRI appearance of muscle denervation. Skelet Radiol 37:397–404CrossRef
18.
go back to reference Kim SJ, Hong SH, Jun WS, Choi JY, Myung JS, Jacobson JA, Lee JW, Choi JA, Kang HS (2011) MR imaging mapping of skeletal muscle denervation in entrapment and compressive neuropathies. Radiographics 31:319–332CrossRefPubMed Kim SJ, Hong SH, Jun WS, Choi JY, Myung JS, Jacobson JA, Lee JW, Choi JA, Kang HS (2011) MR imaging mapping of skeletal muscle denervation in entrapment and compressive neuropathies. Radiographics 31:319–332CrossRefPubMed
19.
go back to reference Leis HT, Sanders TG, Larsen KM, Lancaster-Weiss KJ, Miller MD (2003) Hamstring regrowth following harvesting for ACL reconstruction: the lizard tail phenomenon. J Knee Surg 16:159–164PubMed Leis HT, Sanders TG, Larsen KM, Lancaster-Weiss KJ, Miller MD (2003) Hamstring regrowth following harvesting for ACL reconstruction: the lizard tail phenomenon. J Knee Surg 16:159–164PubMed
20.
go back to reference Lippe J, Spang JT, Leger RR, Arciero RA, Mazzocca AD, Shea KP (2012) Inter-rater agreement of the Goutallier, Patte, and Warner classification scores using preoperative magnetic resonance imaging in patients with rotator cuff tears. Arthroscopy 28:154–159CrossRefPubMed Lippe J, Spang JT, Leger RR, Arciero RA, Mazzocca AD, Shea KP (2012) Inter-rater agreement of the Goutallier, Patte, and Warner classification scores using preoperative magnetic resonance imaging in patients with rotator cuff tears. Arthroscopy 28:154–159CrossRefPubMed
21.
go back to reference Liu H, Chen B, Sun R, Yan C, Zhu C, Xie L, Wang Z (2011) MRI study on tendon regeneration after anterior cruciate ligament reconstruction with hamstring tendon autografts. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:1090–1093PubMed Liu H, Chen B, Sun R, Yan C, Zhu C, Xie L, Wang Z (2011) MRI study on tendon regeneration after anterior cruciate ligament reconstruction with hamstring tendon autografts. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 25:1090–1093PubMed
22.
go back to reference Macleod TD, Snyder-Mackler L, Axe MJ, Buchanan TS (2013) Early regeneration determines long term graft site morphology and function after reconstruction of the anterior cruciate ligament with semitendinosus-gracilis autograft: a case series. Int J Sports Phys Ther 8:256–268PubMedPubMedCentral Macleod TD, Snyder-Mackler L, Axe MJ, Buchanan TS (2013) Early regeneration determines long term graft site morphology and function after reconstruction of the anterior cruciate ligament with semitendinosus-gracilis autograft: a case series. Int J Sports Phys Ther 8:256–268PubMedPubMedCentral
23.
go back to reference Marrale J, Morrisey MC, Haddad FS (2007) A literature review of autograft and allograft anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 15:690–704CrossRefPubMed Marrale J, Morrisey MC, Haddad FS (2007) A literature review of autograft and allograft anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 15:690–704CrossRefPubMed
24.
go back to reference Myer GD, Patterno MV, Ford KR, Quatman CE, Hewett TE (2006) Rehabilitation after anterior cruciate ligament reconstruction: criteria-based progression through the return-to-sport phase. J Orthop Sports Phys Ther 36:385–402CrossRefPubMed Myer GD, Patterno MV, Ford KR, Quatman CE, Hewett TE (2006) Rehabilitation after anterior cruciate ligament reconstruction: criteria-based progression through the return-to-sport phase. J Orthop Sports Phys Ther 36:385–402CrossRefPubMed
25.
go back to reference Nakamae A, Deie M, Yasumoto M, Adachi N, Kobayashi K, Yasunaga Y, Ochi M (2005) Three-dimensional computed tomography imaging evidence of regeneration of the semitendinosus tendon harvested for anterior cruciate ligament reconstruction: a comparison with hamstring muscle strength. J Comp Assist Tomogr 29:241–245CrossRef Nakamae A, Deie M, Yasumoto M, Adachi N, Kobayashi K, Yasunaga Y, Ochi M (2005) Three-dimensional computed tomography imaging evidence of regeneration of the semitendinosus tendon harvested for anterior cruciate ligament reconstruction: a comparison with hamstring muscle strength. J Comp Assist Tomogr 29:241–245CrossRef
26.
go back to reference Nakamura N, Horibe S, Sasaki S, Kitaguchi T, Tagami M, Mitsuoka T, Toritsuka Y, Hamada M, Shino K (2002) Evaluation of active knee flexion and hamstring strength after anterior cruciate ligament reconstruction using hamstring tendons. Arthroscopy 18:598–602CrossRefPubMed Nakamura N, Horibe S, Sasaki S, Kitaguchi T, Tagami M, Mitsuoka T, Toritsuka Y, Hamada M, Shino K (2002) Evaluation of active knee flexion and hamstring strength after anterior cruciate ligament reconstruction using hamstring tendons. Arthroscopy 18:598–602CrossRefPubMed
27.
go back to reference Nardo L, Karampinos DC, Lansdown DA, Carballido-Gamio J, Lee S, Maroldi R, Ma CB, Link TM, Krug R (2014) Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging 39:1178–1185CrossRefPubMed Nardo L, Karampinos DC, Lansdown DA, Carballido-Gamio J, Lee S, Maroldi R, Ma CB, Link TM, Krug R (2014) Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging 39:1178–1185CrossRefPubMed
28.
go back to reference Okahashi K, Sugimoto K, Iwai M, Oshima M, Samma M, Fujisawa Y, Takakura Y (2006) Regeneration of the hamstring tendons after harvesting for arthroscopic anterior cruciate ligament reconstruction: a histological study in 11 patients. Κnee Surg Sports Traumatol Arthrosc 14:542–545CrossRef Okahashi K, Sugimoto K, Iwai M, Oshima M, Samma M, Fujisawa Y, Takakura Y (2006) Regeneration of the hamstring tendons after harvesting for arthroscopic anterior cruciate ligament reconstruction: a histological study in 11 patients. Κnee Surg Sports Traumatol Arthrosc 14:542–545CrossRef
29.
go back to reference Papandrea P, Vulpianni MC, Ferretti A, Conteduca F (2000) Regeneration of the semitendinosus tendon harvested for anterior cruciate ligament reconstruction. Evaluation using ultrasonography. Am J Sports Med 28:556–561PubMed Papandrea P, Vulpianni MC, Ferretti A, Conteduca F (2000) Regeneration of the semitendinosus tendon harvested for anterior cruciate ligament reconstruction. Evaluation using ultrasonography. Am J Sports Med 28:556–561PubMed
30.
go back to reference Rahr-Wagner L, Thillemann TM, PedersenAB Lind M (2014) Comparison of hamstring tendon and patellar tendon grafts in anterior cruciate ligament reconstruction in a nationwide population—based cohort study: results of the Danish registry of knee ligament reconstruction. Am J Sports Med 42:278–284CrossRefPubMed Rahr-Wagner L, Thillemann TM, PedersenAB Lind M (2014) Comparison of hamstring tendon and patellar tendon grafts in anterior cruciate ligament reconstruction in a nationwide population—based cohort study: results of the Danish registry of knee ligament reconstruction. Am J Sports Med 42:278–284CrossRefPubMed
31.
go back to reference Rispoli DM, Sanders TG, Miller MD, Morrison WB (2001) Magnetic resonance imaging at different time periods following hamstring harvest for anterior cruciate ligament reconstruction. Arthroscopy 17:2–8CrossRefPubMed Rispoli DM, Sanders TG, Miller MD, Morrison WB (2001) Magnetic resonance imaging at different time periods following hamstring harvest for anterior cruciate ligament reconstruction. Arthroscopy 17:2–8CrossRefPubMed
32.
go back to reference Shaerf DA, Pastides PS, Sarraf KM, Willis-Owen CA (2014) Anterior cruciate ligament reconstruction best practice: a review of graft choice. World J Ortop 18(5):23–29CrossRef Shaerf DA, Pastides PS, Sarraf KM, Willis-Owen CA (2014) Anterior cruciate ligament reconstruction best practice: a review of graft choice. World J Ortop 18(5):23–29CrossRef
33.
go back to reference Simonian PT, Harrison SD, Cooley VJ, Escabedo EM, Deneka DA, Larson RV (1997) Assessment of morbidity of semitendinosus and gracilis tendon harvest for ACL reconstruction. Am J Knee Surg 10:54–59PubMed Simonian PT, Harrison SD, Cooley VJ, Escabedo EM, Deneka DA, Larson RV (1997) Assessment of morbidity of semitendinosus and gracilis tendon harvest for ACL reconstruction. Am J Knee Surg 10:54–59PubMed
34.
go back to reference Snow BJ, Wilcox JJ, Burks RT, Greis PE (2012) Evaluation of muscle size and fatty infiltration with MRI nine to eleven years following hamstring harvest for ACL reconstruction. J Bone Joint Surg Am 94:1274–1282CrossRefPubMed Snow BJ, Wilcox JJ, Burks RT, Greis PE (2012) Evaluation of muscle size and fatty infiltration with MRI nine to eleven years following hamstring harvest for ACL reconstruction. J Bone Joint Surg Am 94:1274–1282CrossRefPubMed
35.
go back to reference Tadokoro K, Matsui N, Yagi M, Kuroda R, Kurosaka M, Yoshiva S (2004) Evaluation of hamstring strength and tendon regrowth after harvesting for anterior cruciate ligament reconstruction. Am J Sports Med 32(7):1644–1650CrossRefPubMed Tadokoro K, Matsui N, Yagi M, Kuroda R, Kurosaka M, Yoshiva S (2004) Evaluation of hamstring strength and tendon regrowth after harvesting for anterior cruciate ligament reconstruction. Am J Sports Med 32(7):1644–1650CrossRefPubMed
36.
go back to reference Takeda Y, Kashiwaguchi S, Matsuura T, Higashida T, Minato A (2006) Hamstring muscle function after tendon harvest for anterior cruciate ligament reconstruction: evaluation with T2 relaxation time of magnetic resonance imaging. Am J Sports Med 34:281–288CrossRefPubMed Takeda Y, Kashiwaguchi S, Matsuura T, Higashida T, Minato A (2006) Hamstring muscle function after tendon harvest for anterior cruciate ligament reconstruction: evaluation with T2 relaxation time of magnetic resonance imaging. Am J Sports Med 34:281–288CrossRefPubMed
37.
go back to reference Thompson SM, Reilly P, Emery RJ, Bull AM (2012) A comparison of the degree of retraction of full-thickness supraspinatus tears with the Goutallier grading system. J Shoulder Elbow Surg 21:749–753CrossRefPubMed Thompson SM, Reilly P, Emery RJ, Bull AM (2012) A comparison of the degree of retraction of full-thickness supraspinatus tears with the Goutallier grading system. J Shoulder Elbow Surg 21:749–753CrossRefPubMed
38.
go back to reference Viola RW, Sterett WI, Newfield D, Steadman JR, Torry MR (2000) Internal and external tibial rotation strength after anterior cruciate ligament reconstruction using ipsilateral semitendinosus and gracilis tendon autografts. Am J Sports Med 28:552–1525PubMed Viola RW, Sterett WI, Newfield D, Steadman JR, Torry MR (2000) Internal and external tibial rotation strength after anterior cruciate ligament reconstruction using ipsilateral semitendinosus and gracilis tendon autografts. Am J Sports Med 28:552–1525PubMed
39.
go back to reference Williams GN, Snyder-Mackler L, Barrance PJ, Axe MJ, Buchanan TS (2004) Muscle and tendon morphology after reconstruction of the anterior cruciate ligament with autologous semitendinosus-gracilis graft. J Bone Joint Surg Am 86-A:1936–1946CrossRefPubMed Williams GN, Snyder-Mackler L, Barrance PJ, Axe MJ, Buchanan TS (2004) Muscle and tendon morphology after reconstruction of the anterior cruciate ligament with autologous semitendinosus-gracilis graft. J Bone Joint Surg Am 86-A:1936–1946CrossRefPubMed
Metadata
Title
The natural history of donor hamstrings unit after anterior cruciate ligament reconstruction: a prospective MRI scan assessment
Authors
Ioannis Tsifountoudis
Ilias Bisbinas
Ioannis Kalaitzoglou
George Markopoulos
Aphrodite Haritandi
Athanasios Dimitriadis
Stergios Papastergiou
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 5/2017
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-015-3732-3

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