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Knee Surgery, Sports Traumatology, Arthroscopy
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 7/2016

01-07-2016 | Experimental Study

Multilayer scaffolds in orthopaedic tissue engineering

Authors: Kivanc Atesok, M. Nedim Doral, Jon Karlsson, Kenneth A. Egol, Laith M. Jazrawi, Paulo G. Coelho, Amaury Martinez, Tomoyuki Matsumoto, Brett D. Owens, Mitsuo Ochi, Shepard R. Hurwitz, Anthony Atala, Freddie H. Fu, Helen H. Lu, Scott A. Rodeo

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 7/2016

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Abstract

Purpose

The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration.

Methods

Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces.

Results

In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications.

Conclusions

Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.
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Metadata
Title
Multilayer scaffolds in orthopaedic tissue engineering
Authors
Kivanc Atesok
M. Nedim Doral
Jon Karlsson
Kenneth A. Egol
Laith M. Jazrawi
Paulo G. Coelho
Amaury Martinez
Tomoyuki Matsumoto
Brett D. Owens
Mitsuo Ochi
Shepard R. Hurwitz
Anthony Atala
Freddie H. Fu
Helen H. Lu
Scott A. Rodeo
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 7/2016
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-014-3453-z

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