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01-04-2020 | Aminoglycoside | Understanding the Disease

Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin

Authors: J. J. Rouby, C. Sole-Lleonart, J. Rello, the European Investigators Network for Nebulized Antibiotics in Ventilator-associated Pneumonia

Published in: Intensive Care Medicine | Issue 4/2020

Excerpt

The use of nebulized antibiotics for treating ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) increases worldwide. There is a paradox, however, between the large body of experimental evidence supporting the administration of nebulized rather than intravenous aminoglycosides and colistin to treat inoculation pneumonia caused by GNB [1, 2], and the paucity of clinical studies confirming such a benefit in VAP. Based on the recommendations of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) [3, 4], the present article examines this apparent contradiction and suggests some directions for further research and clinical practice. …

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Title: Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin
Authors: J. J. Rouby
C. Sole-Lleonart
J. Rello
the European Investigators Network for Nebulized Antibiotics in Ventilator-associated Pneumonia
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Aminoglycoside
Antibiotic
Nosocomial Pneumonia
Pneumonia
Published in: Intensive Care Medicine / Issue 4/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05890-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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