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Published in: Intensive Care Medicine 5/2019

01-05-2019 | Antibiotic | Editorial

Personalized antibiotic dosing for the critically ill

Authors: Jason A. Roberts, Claire Roger, Jan J. De Waele

Published in: Intensive Care Medicine | Issue 5/2019

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Excerpt

Therapeutic antibiotic exposures (concentrations) have been demonstrated to improve clinical cure, reduce drug toxicity and even reduce mortality in infected critically ill patients [13]. With persisting high morbidity and mortality associated with sepsis and septic shock in these patients, optimisation of antibiotic exposures is a key treatment intervention. However, there are various patient, diagnostic, treatment and pathology-related factors which complicate this process. A dosing strategy that is personalised to the individual’s needs is required during critical illness to ensure these exposures associated with patient benefit are achieved [4]. …
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Metadata
Title
Personalized antibiotic dosing for the critically ill
Authors
Jason A. Roberts
Claire Roger
Jan J. De Waele
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Keyword
Antibiotic
Published in
Intensive Care Medicine / Issue 5/2019
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-019-05522-3

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