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01-08-2018 | Editorial

Haloperidol and delirium in the ICU: the finger pointing to the moon

Author: Nicola Latronico

Published in: Intensive Care Medicine | Issue 8/2018

Excerpt

Haloperidol, the neuroleptic agent par excellence, was synthesized 60 years ago in February 1958. Since then it has been used in hundreds of thousands of patients with schizophrenia and other psychoses, particularly for the management of psychosis-induced agitation [1], and is included in the World Health Organisation’s list of essential medicines. …

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Collet MO, Caballero J, Sonneville R, Bozza FA, Nydahl P, Schandl A, Woien H, Citerio G, van den Boogaard M, Hastbacka J, Haenggi M, Colpaert K, Rose L, Barbateskovic M, Lange T, Jensen A, Krog MB, Egerod I, Nibro HL, Wetterslev J, Perner A, the AID-ICU Cohort Study Co-authors (2018) Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Med. https://doi.org/10.1007/s00134-018-5204-y PubMedCrossRef

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Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, Hughes CG, Chandrasekhar R, Pun BT, Boehm LM, Elstad MR, Goodman RB, Bernard GR, Dittus RS, Ely EW (2018) Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med 6:213–222CrossRefPubMed

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Salluh JIF; Latronico N, (2018) Does this critically ill patient with delirium require any drug treatment? Intensive Care Med

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van den Boogaard M, Slooter AJC, Bruggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P, Investigators RS, van der Woude MCE, Besselink A, Hofstra LS, Spronk PE, van den Bergh W, Donker DW, Fuchs M, Karakus A, Koeman M, van Duijnhoven M, Hannink G (2018) Effect of haloperidol on survival among critically ill adults with a high risk of delirium: the REDUCE randomized clinical trial. JAMA 319:680–690CrossRefPubMedPubMedCentral

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Title: Haloperidol and delirium in the ICU: the finger pointing to the moon
Author: Nicola Latronico
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 8/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5276-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Haloperidol and delirium in the ICU: the finger pointing to the moon

Excerpt

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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