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Published in:

01-10-2017 | Review

Critical illness-associated diaphragm weakness

Authors: Martin Dres, Ewan C. Goligher, Leo M. A. Heunks, Laurent J. Brochard

Published in: Intensive Care Medicine | Issue 10/2017

Abstract

Diaphragm weakness is highly prevalent in critically ill patients. It may exist prior to ICU admission and may precipitate the need for mechanical ventilation but it also frequently develops during the ICU stay. Several risk factors for diaphragm weakness have been identified; among them sepsis and mechanical ventilation play central roles. We employ the term critical illness-associated diaphragm weakness to refer to the collective effects of all mechanisms of diaphragm injury and weakness occurring in critically ill patients. Critical illness-associated diaphragm weakness is consistently associated with poor outcomes including increased ICU mortality, difficult weaning, and prolonged duration of mechanical ventilation. Bedside techniques for assessing the respiratory muscles promise to improve detection of diaphragm weakness and enable preventive or curative strategies. Inspiratory muscle training and pharmacological interventions may improve respiratory muscle function but data on clinical outcomes remain limited.

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Title: Critical illness-associated diaphragm weakness
Authors: Martin Dres
Ewan C. Goligher
Leo M. A. Heunks
Laurent J. Brochard
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 10/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-017-4928-4

At a glance: The STEP trials

Springer Medicine

Critical illness-associated diaphragm weakness

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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