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Intensive Care Medicine
Published in: Intensive Care Medicine 4/2017

01-04-2017 | Editorial

Small observational studies and data sharing: fuel for debate and coins for the piggy bank of evidence

Author: Daniele Poole

Published in: Intensive Care Medicine | Issue 4/2017

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Excerpt

In an article recently published in Intensive Care Medicine, Constant et al. [1] report the results of their observational study investigating the effectiveness of targeted temperature management (TTM) in improving outcome in patients who were successfully resuscitated after cardiac arrest during surgical procedures [2]. The authors retrospectively reviewed 101 cases that occurred between 2008 and 2013 in 11 centres, 30 treated with TTM. Using logistic regression TTM did not turn out to be an independent predictor of favourable neurological outcome. Consistently with data from the literature, shockable rhythms were strongly protective while emergency surgery worsened the prognosis [2, 3]. …
Literature
1.
Constant AL, Mongardon N, Morelot Q, Pichon N, Grimaldi D, Bordenave L, Soummer A, Sauneuf B, Merceron S, Ricome S, Misset B, Bruel C, Schnell D, Boisramé-Helms J, Dubuisson E, Brunet J, Lasocki S, Cronier P, Bouhemad B, Carreira S, Begot E, Vandenbunder B, Dhonneur G, Jullien P, Resche-rigon M, Bedos JP, Montlahuc C, Legriel S (2017) Targeted temperature management after intraoperative cardiac arrest: a multicenter retrospective study. Intensive Care Med. doi:10.​1007/​s00134-017-4709-0
2.
Dumas F, Grimaldi D, Zuber B et al (2011) Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients? Insights from a large registry. Circulation 123(8):877–886CrossRefPubMed
3.
Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270(24):2957–2963CrossRefPubMed
4.
Katz MH (2003) Multivariable analysis: a primer for readers of medical research. Ann Intern Med 138(8):644–650CrossRefPubMed
5.
Babyak MA (2004) What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 66(3):411–421PubMed
6.
Harrell FE Jr, Lee KL, Mark DB (1996) Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 15(4):361–387CrossRefPubMed
7.
Rosenbaum PR, Rubin DB (1983) The central role of the propensity score in observational studies for causal effects. Biometrika 70(1):41–55CrossRef
8.
Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165(6):710–718CrossRefPubMed
9.
Austin PC (2011) An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res 46(3):399–424CrossRef
10.
Freemantle N, Marston L, Walters K, Wood J, Reynolds MR, Petersen I (2013) Making inferences on treatment effects from real world data: propensity scores, confounding by indication, and other perils for the unwary in observational research. BMJ 347:f6409CrossRefPubMed
11.
Poole D, Nattino G, Bertolini G (2014) Overoptimism in the interpretation of statistics: the ethical role of statistical reviewers in medical journals. Intensive Care Med 40(12):1927–1929CrossRefPubMed
12.
Bernard SA, Gray TW, Buist MD et al (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346(8):557–563CrossRefPubMed
13.
Hypothermia after Cardiac Arrest Study Group (2002) Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346(8):549–556CrossRef
14.
Metadata
Title
Small observational studies and data sharing: fuel for debate and coins for the piggy bank of evidence
Author
Daniele Poole
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 4/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4696-1

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