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Published in: Intensive Care Medicine 10/2012

01-10-2012 | Review

The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome

Authors: Weidun Alan Guo, Paul R. Knight, Krishnan Raghavendran

Published in: Intensive Care Medicine | Issue 10/2012

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Abstract

The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor and evolutionary member of the immunoglobulin superfamily that is involved in the host response to infection, injury, and inflammation. It exists in two forms: membrane-bound and soluble forms (sRAGE). RAGE recognizes a variety of ligands and, via a receptor-driven signaling cascade, activates the transcription factor NF-κB, leading to the expression of proinflammatory cytokines. The soluble form, sRAGE, is a decoy receptor and competitively inhibits membrane RAGE activation. RAGE is constitutively expressed abundantly in the lung under basal conditions. This expression is enhanced during inflammatory states such as with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). This review summarizes the characteristics of RAGE, RAGE isoforms, RAGE ligands, and signaling pathways in the pathogenesis of ALI and ARDS. Additionally, the review explores the potential of RAGE as an important therapeutic target in ALI/ARDS.
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Metadata
Title
The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome
Authors
Weidun Alan Guo
Paul R. Knight
Krishnan Raghavendran
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 10/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2624-y

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