Skip to main content
Top
Published in: Intensive Care Medicine 8/2012

01-08-2012 | Editorial

Candida colonization in ventilated ICU patients: no longer a bystander!

Authors: Jean-Damien Ricard, Damien Roux

Published in: Intensive Care Medicine | Issue 8/2012

Login to get access

Excerpt

The role and consequences of the presence of Candida spp. in the lungs of mechanically ventilated patients are receiving growing attention as we gain insight into the interaction between fungi and bacteria in diseases in general [1] and in lung infection in particular [2]. In a 2009 issue of Intensive Care Medicine, Meersseman et al. provided us with convincing data on the absence of Candida pneumonia in the ICU despite a high rate of colonization (53 %) [3]. These authors could however only speculate on the significance of the presence of Candida spp. in their patients. We ended our accompanying editorial by stating that Candida lung colonization may have a significant role in bacterial pneumonia development [4]. This statement was prompted by several clinical and experimental clues. …
Literature
1.
go back to reference Peleg AY, Hogan DA, Mylonakis E (2010) Medically important bacterial-fungal interactions. Nat Rev Microbiol 8:340–349PubMedCrossRef Peleg AY, Hogan DA, Mylonakis E (2010) Medically important bacterial-fungal interactions. Nat Rev Microbiol 8:340–349PubMedCrossRef
2.
go back to reference Roux D, Gaudry S, Dreyfuss D, El-Benna J, de Prost N, Denamur E, Saumon G, Ricard JD (2009) Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat. Crit Care Med 37:1062–1067PubMedCrossRef Roux D, Gaudry S, Dreyfuss D, El-Benna J, de Prost N, Denamur E, Saumon G, Ricard JD (2009) Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat. Crit Care Med 37:1062–1067PubMedCrossRef
3.
go back to reference Meersseman W, Lagrou K, Spriet I, Verbeken E, Peetermans W, Van Wijngaerden E (2009) Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study. Intensive Care Med 35:1526–1531PubMedCrossRef Meersseman W, Lagrou K, Spriet I, Verbeken E, Peetermans W, Van Wijngaerden E (2009) Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study. Intensive Care Med 35:1526–1531PubMedCrossRef
4.
go back to reference Ricard JD, Roux D (2009) Candida pneumonia in the ICU: myth or reality? Intensive Care Med 35:1500–1502PubMedCrossRef Ricard JD, Roux D (2009) Candida pneumonia in the ICU: myth or reality? Intensive Care Med 35:1500–1502PubMedCrossRef
5.
go back to reference Azoulay E, Timsit JF, Tafflet M, de Lassence A, Darmon M, Zahar JR, Adrie C, Garrouste-Orgeas M, Cohen Y, Mourvillier B, Schlemmer B (2006) Candida colonization of the respiratory tract and subsequent pseudomonas ventilator-associated pneumonia. Chest 129:110–117PubMedCrossRef Azoulay E, Timsit JF, Tafflet M, de Lassence A, Darmon M, Zahar JR, Adrie C, Garrouste-Orgeas M, Cohen Y, Mourvillier B, Schlemmer B (2006) Candida colonization of the respiratory tract and subsequent pseudomonas ventilator-associated pneumonia. Chest 129:110–117PubMedCrossRef
6.
go back to reference Nseir S, Jozefowicz E, Cavestri B, Sendid B, Di Pompeo C, Dewavrin F, Favory R, Roussel-Delvallez M, Durocher A (2007) Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study. Intensive Care Med 33:137–142PubMedCrossRef Nseir S, Jozefowicz E, Cavestri B, Sendid B, Di Pompeo C, Dewavrin F, Favory R, Roussel-Delvallez M, Durocher A (2007) Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study. Intensive Care Med 33:137–142PubMedCrossRef
7.
go back to reference Roux D, Gaudry S, Khoy-Ear L, Denamur E, Dreyfuss D, Ricard JD (2009) Candida albicans airway colonization favors bacterial pneumonia [abstract]. Am J Respir Crit Care Med 181:A3269 Roux D, Gaudry S, Khoy-Ear L, Denamur E, Dreyfuss D, Ricard JD (2009) Candida albicans airway colonization favors bacterial pneumonia [abstract]. Am J Respir Crit Care Med 181:A3269
8.
go back to reference Hamet M, Pavon A, Dalle F, Prin S, Pechinot A, Quenot J, Charles P (2012) Candida sp. airway colonization could promote antibiotic-resistant bacteria selection in the patients with suspected ventilator-associated pneumonia. Intensive Care Med 38. doi:10.1007/s00134-012-2584-2 Hamet M, Pavon A, Dalle F, Prin S, Pechinot A, Quenot J, Charles P (2012) Candida sp. airway colonization could promote antibiotic-resistant bacteria selection in the patients with suspected ventilator-associated pneumonia. Intensive Care Med 38. doi:10.​1007/​s00134-012-2584-2
9.
go back to reference Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323–2329PubMedCrossRef Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323–2329PubMedCrossRef
10.
go back to reference Delisle MS, Williamson DR, Perreault MM, Albert M, Jiang X, Heyland DK (2008) The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients. J Crit Care 23:11–17PubMedCrossRef Delisle MS, Williamson DR, Perreault MM, Albert M, Jiang X, Heyland DK (2008) The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients. J Crit Care 23:11–17PubMedCrossRef
11.
go back to reference Williamson DR, Albert M, Perreault MM, Delisle MS, Muscedere J, Rotstein C, Jiang X, Heyland DK (2011) The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia. Can J Anaesth 58:275–284PubMedCrossRef Williamson DR, Albert M, Perreault MM, Delisle MS, Muscedere J, Rotstein C, Jiang X, Heyland DK (2011) The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia. Can J Anaesth 58:275–284PubMedCrossRef
12.
go back to reference Carlson E (1982) Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality. Infect Immun 38:921–924PubMed Carlson E (1982) Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality. Infect Immun 38:921–924PubMed
13.
go back to reference Carlson E (1983) Enhancement by Candida albicans of Staphylococcus aureus, Serratia marcescens, and Streptococcus faecalis in the establishment of infection in mice. Infect Immun 39:193–197PubMed Carlson E (1983) Enhancement by Candida albicans of Staphylococcus aureus, Serratia marcescens, and Streptococcus faecalis in the establishment of infection in mice. Infect Immun 39:193–197PubMed
14.
go back to reference McAlester G, O’Gara F, Morrissey JP (2008) Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. J Med Microbiol 57:563–569PubMedCrossRef McAlester G, O’Gara F, Morrissey JP (2008) Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. J Med Microbiol 57:563–569PubMedCrossRef
15.
go back to reference Meduri GU (2002) Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome. Crit Care 6:24–29PubMedCrossRef Meduri GU (2002) Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome. Crit Care 6:24–29PubMedCrossRef
16.
go back to reference Meduri GU, Kanangat S, Stefan J, Tolley E, Schaberg D (1999) Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria. Am J Respir Crit Care Med 160:961–967PubMed Meduri GU, Kanangat S, Stefan J, Tolley E, Schaberg D (1999) Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria. Am J Respir Crit Care Med 160:961–967PubMed
17.
go back to reference Roux D, Khoy-Ear L, Gaudry S, Bex J, Denamur E, Dreyfuss D, Ricard JD (2010) Antifungal treatment prevents bacterial pneumonia during airway fungal colonization [abstract]. Am J Respir Crit Care Med 181:A3245 Roux D, Khoy-Ear L, Gaudry S, Bex J, Denamur E, Dreyfuss D, Ricard JD (2010) Antifungal treatment prevents bacterial pneumonia during airway fungal colonization [abstract]. Am J Respir Crit Care Med 181:A3245
18.
go back to reference Roux D, Ricard J-D (2011) Novel therapies for Pseudomonas aeruginosa pneumonia. Infect Disord Drug Targets 11:389–394PubMed Roux D, Ricard J-D (2011) Novel therapies for Pseudomonas aeruginosa pneumonia. Infect Disord Drug Targets 11:389–394PubMed
Metadata
Title
Candida colonization in ventilated ICU patients: no longer a bystander!
Authors
Jean-Damien Ricard
Damien Roux
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 8/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2587-z

Other articles of this Issue 8/2012

Intensive Care Medicine 8/2012 Go to the issue