Top

Published in:

01-06-2012 | Editorial

Myeloid-derived suppressor cells in sepsis: friend or foe?

Authors: Alex G. Cuenca, Lyle L. Moldawer

Published in: Intensive Care Medicine | Issue 6/2012

Excerpt

Through improvements in supportive care measures over the last few decades, such as those guidelines based on the ‘Surviving Sepsis Campaign’ and early goal-directed therapy trials, we have been able to help most of our patients survive through the initial systemic inflammatory response period [1, 2]. Unfortunately, a significant portion of patients still have protracted hospital courses and eventually succumb to late nosocomial infections [3]. These late sepsis-associated morbidities are thought to be related to global host immunosuppression. …

Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM, Surviving Sepsis Campaign Management Guidelines C (2004) Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32:858–873PubMedCrossRef

Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative G (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377PubMedCrossRef

Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725–2732PubMedCrossRef

Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, Heyworth PG, Efron PA, Moldawer LL (2010) A paradoxical role for myeloid derived suppressor cells in sepsis and trauma. Mol Med 17:281–292PubMed

Hotchkiss RS, Opal S (2010) Immunotherapy for sepsis–a new approach against an ancient foe. N Engl J Med 363:87–89PubMedCrossRef

Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25:1298–1307PubMedCrossRef

Hiramatsu M, Hotchkiss RS, Karl IE, Buchman TG (1997) Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7:247–253PubMedCrossRef

Efron PA, Martins A, Minnich D, Tinsley K, Ungaro R, Bahjat FR, Hotchkiss R, Clare-Salzler M, Moldawer LL (2004) Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol 173:3035–3043PubMed

Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306:2594–2605PubMedCrossRef

10.

Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, Poitevin F, Bohe J, Lepape A, Ayala A, Monneret G (2009) Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127(−)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 35:678–686PubMedCrossRef

11.

Venet F, Chung CS, Monneret G, Huang X, Horner B, Garber M, Ayala A (2008) Regulatory T cell populations in sepsis and trauma. J Leukoc Biol 83:523–535PubMedCrossRef

12.

Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O’Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL (2007) MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204:1463–1474PubMedCrossRef

13.

Sander LE, Sackett SD, Dierssen U, Beraza N, Linke RP, Muller M, Blander JM, Tacke F, Trautwein C (2010) Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J Exp Med 207:1453–1464PubMedCrossRef

14.

Derive M, Bouazza Y, Alauzet C, Gibot S (2012) Myeloid-derived suppressor cells control microbial sepsis. Intensive Care Med. doi:10.1007/s00134-012-2574-4

15.

Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O’Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL (2010) Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol 186:195–202PubMedCrossRef

16.

Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162–174PubMedCrossRef

17.

Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, Heyworth PG, Efron PA, Moldawer LL (2011) A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med 17:281–292PubMedCrossRef

Title: Myeloid-derived suppressor cells in sepsis: friend or foe?
Authors: Alex G. Cuenca
Lyle L. Moldawer
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 6/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-012-2575-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Myeloid-derived suppressor cells in sepsis: friend or foe?

Excerpt

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 6/2012

Outcome of critically ill lung transplant candidates on invasive respiratory support

Less blood loss with tetrastarch

Intensive care medicine: finding its way in the “European labyrinth”: reply to Van Aken et al.

Outcomes in children with refractory pneumonia supported with extracorporeal membrane oxygenation

In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial

Comment on Rubulotta et al.: Intensive care medicine: finding its way in the “European labyrinth”