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Intensive Care Medicine
Published in: Intensive Care Medicine 5/2012

01-05-2012 | Original

Safety and efficacy of a fully closed-loop control ventilation (IntelliVent-ASV®) in sedated ICU patients with acute respiratory failure: a prospective randomized crossover study

Authors: Jean-Michel Arnal, Marc Wysocki, Dominik Novotni, Didier Demory, Ricardo Lopez, Stéphane Donati, Isabelle Granier, Gaëlle Corno, Jacques Durand-Gasselin

Published in: Intensive Care Medicine | Issue 5/2012

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Abstract

Purpose

IntelliVent-ASV® is a development of adaptive support ventilation (ASV) that automatically adjusts ventilation and oxygenation parameters. This study assessed the safety and efficacy of IntelliVent-ASV® in sedated intensive care unit (ICU) patients with acute respiratory failure.

Methods

This prospective randomized crossover comparative study was conducted in a 12-bed ICU in a general hospital. Two periods of 2 h of ventilation in randomly applied ASV or IntelliVent-ASV® were compared in 50 sedated, passively ventilated patients. Tidal volume (V T), respiratory rate (RR), inspiratory pressure (P INSP), SpO2 and ETCO2 were continuously monitored and recorded breath by breath. Mean values over the 2-h period were calculated. Respiratory mechanics, plateau pressure (P PLAT) and blood gas exchanges were measured at the end of each period.

Results

There was no safety issue requiring premature interruption of IntelliVent-ASV®. Minute ventilation (MV) and V T decreased from 7.6 (6.5–9.5) to 6.8 (6.0–8.0) L/min (p < 0.001) and from 8.3 (7.8–9.0) to 8.1 (7.7–8.6) mL/kg PBW (p = 0.003) during IntelliVent-ASV® as compared to ASV. P PLAT and FiO2 decreased from 24 (20–29) to 20 (19–25) cmH2O (p = 0.005) and from 40 (30–50) to 30 (30–39) % (p < 0.001) during IntelliVent-ASV® as compared to ASV. RR, P INSP, and PEEP decreased as well during IntelliVent-ASV® as compared to ASV. Respiratory mechanics, pH, PaO2 and PaO2/FiO2 ratio were not different but PaCO2 was slightly higher during IntelliVent-ASV® as compared to ASV.

Conclusions

In passive patients with acute respiratory failure, IntelliVent-ASV® was safe and able to ventilate patients with less pressure, volume and FiO2 while producing the same results in terms of oxygenation.
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Metadata
Title
Safety and efficacy of a fully closed-loop control ventilation (IntelliVent-ASV®) in sedated ICU patients with acute respiratory failure: a prospective randomized crossover study
Authors
Jean-Michel Arnal
Marc Wysocki
Dominik Novotni
Didier Demory
Ricardo Lopez
Stéphane Donati
Isabelle Granier
Gaëlle Corno
Jacques Durand-Gasselin
Publication date
01-05-2012
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 5/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-012-2548-6

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