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Intensive Care Medicine

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Open Access 01-01-2011 | Original

Clinicians’ response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO₂

Authors: Aafke Elizabeth de Graaff, Dave Anton Dongelmans, Jan Maria Binnekade, Evert de Jonge

Published in: Intensive Care Medicine | Issue 1/2011

Abstract

Purpose

Hyperoxia may induce pulmonary injury and may increase oxidative stress. In this retrospective database study we aimed to evaluate the response to hyperoxia by intensivists in a Dutch academic intensive care unit.

Methods

All arterial blood gas (ABG) data from mechanically ventilated patients from 2005 until 2009 were extracted from an electronic storage database of a mixed 32-bed intensive care unit in a university hospital in Amsterdam. Mechanical ventilation settings at the time of the ABG tests were retrieved.

Results

The results of 126,778 ABG tests from 5,498 mechanically ventilated patients were retrieved including corresponding ventilator settings. In 28,222 (22%) of the ABG tests the arterial oxygen tension (PaO₂) was >16 kPa (120 mmHg). In only 25% of the tests with PaO₂ >16 kPa (120 mmHg) was the fraction of inspired oxygen (FiO₂) decreased. Hyperoxia was accepted without adjustment in ventilator settings if FiO₂ was 0.4 or lower.

Conclusion

Hyperoxia is frequently seen but in most cases does not lead to adjustment of ventilator settings if FiO₂ <0.41. Implementation of guidelines concerning oxygen therapy should be improved and further research is needed concerning the effects of frequently encountered hyperoxia.

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Title: Clinicians’ response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2
Authors: Aafke Elizabeth de Graaff
Dave Anton Dongelmans
Jan Maria Binnekade
Evert de Jonge
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 1/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-2025-z

At a glance: The STEP trials

Springer Medicine

Clinicians’ response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO₂

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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