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Open Access 01-09-2009 | Original

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality

Authors: Melanie van der Heijden, Peter Pickkers, Geerten P. van Nieuw Amerongen, Victor W. M. van Hinsbergh, Martijn P. W. J. M. Bouw, Johannes G. van der Hoeven, A. B. Johan Groeneveld

Published in: Intensive Care Medicine | Issue 9/2009

Abstract

Purpose

To investigate whether angiopoietin-2, von Willebrand factor (VWF) and angiopoietin-1 relate to surrogate indicators of vascular permeability, pulmonary dysfunction and intensive care unit (ICU) mortality throughout the course of septic shock.

Methods

In 50 consecutive mechanically ventilated septic shock patients, plasma angiopoietin-2, VWF and angiopoietin-1 levels and fluid balance, partial pressure of oxygen/inspiratory oxygen fraction and the oxygenation index as indicators of vascular permeability and pulmonary dysfunction, respectively, were measured until day 28.

Results

Angiopoietin-2 positively related to the fluid balance and pulmonary dysfunction, was higher in non-survivors than in survivors and independently predicted non-survival throughout the course of septic shock. VWF inversely related to the fluid balance and pulmonary dysfunction throughout the course of septic shock, was comparable between survivors and non-survivors and predicted non-survival on day 0 only. Angiopoietin-1 positively related to pulmonary dysfunction throughout the course, but did not differ between survivors and non-survivors.

Conclusions

In contrast to VWF, plasma angiopoietin-2 positively relates to fluid balance, pulmonary dysfunction and mortality throughout the course of septic shock, in line with a suggested mediator role of the protein.

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Title: Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality
Authors: Melanie van der Heijden
Peter Pickkers
Geerten P. van Nieuw Amerongen
Victor W. M. van Hinsbergh
Martijn P. W. J. M. Bouw
Johannes G. van der Hoeven
A. B. Johan Groeneveld
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 9/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1560-y

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Springer Medicine

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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