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01-05-2009 | Original

Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management

Authors: Alexandre Boyer, Frederic Vargas, Fanny Coste, Elodie Saubusse, Yves Castaing, Georges Gbikpi-Benissan, Gilles Hilbert, Didier Gruson

Published in: Intensive Care Medicine | Issue 5/2009

Abstract

Purpose

Surgical treatment is crucial in the management of necrotizing soft tissue infections (NSTIs). The aim of this study was to determine the influence of surgical procedure timing on hospital mortality in severe NSTI.

Methods

A retrospective study including 106 patients was conducted in a medical intensive care unit equipped with a hyperbaric chamber. Data regarding pre-existing conditions, intensive care and surgical management were included in a logistic regression model to determine independent factors associated with hospital mortality.

Results

Overall hospital mortality was 40.6%. In multivariate analysis, underlying cardiovascular disease, SAPS II, abdominoperineal compared to limb localization, time from the first signs to diagnosis <72 h, and time from diagnosis to surgical treatment >14 h in patients with septic shock were independently associated with hospital mortality.

Conclusion

In patients with NSTI and septic shock, hospital mortality is influenced by the timing of surgical treatment.

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Title: Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management
Authors: Alexandre Boyer
Frederic Vargas
Fanny Coste
Elodie Saubusse
Yves Castaing
Georges Gbikpi-Benissan
Gilles Hilbert
Didier Gruson
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1373-4

At a glance: The STEP trials

Springer Medicine

Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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