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Intensive Care Medicine

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01-12-2008 | Pediatric Brief Report

Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children

Authors: Adrian Plunkett, Rachel S. Agbeko, KaWah Li, Steve E. Humphries, Nigel J. Klein, Mark J. Peters

Published in: Intensive Care Medicine | Issue 12/2008

Abstract

Objective

The D allele of the I/D polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with an increased risk of ARDS in critically ill adults and severity of bronchopulmonary dysplasia in pre-term infants. We hypothesised that the presence of the hypoxia-associated ACE D allele would increase susceptibility to acute hypoxic respiratory failure (AHRF) in a cohort of critically ill children.

Design and setting

Single-centre prospective observational cohort study.

Patients

Children under 16 years of age requiring admission to a tertiary general PICU.

Measurements and results

A total of 216 Caucasian patients were enrolled. Thirty (13.9%) children developed AHRF and 13 were diagnosed with ARDS (6.0%). There was no significant difference in ACE D allele frequency between patient groups with or without AHRF (0.53 vs. 0.54).

Conclusions

Variation in ACE activity does not influence the development of paediatric AHRF. This may reflect a different pathogenesis from adult ARDS.

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Title: Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children
Authors: Adrian Plunkett
Rachel S. Agbeko
KaWah Li
Steve E. Humphries
Nigel J. Klein
Mark J. Peters
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 12/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1260-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

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