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Intensive Care Medicine
Published in: Intensive Care Medicine 12/2008

Open Access 01-12-2008 | Correspondence

Microcirculation and multi-organ failure in patients with sepsis

Authors: C. A. den Uil, W. K. Lagrand, J. J. Brugts, P. E. Spronk

Published in: Intensive Care Medicine | Issue 12/2008

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Excerpt

With great interest, we read the article by Trzeciak et al. who made a commendable effort to investigate whether an improvement in SOFA score over the first 24 h in patients with sepsis was associated with an increase in sublingual microcirculatory perfusion. The authors demonstrated a significant increase in median microvascular flow index (MFI) for SOFA improvers versus non-improvers (+0.23 vs. −0.05, respectively) [1]. Although we appreciate these interesting findings, we would like to raise several comments. …
Literature
1.
Trzeciak S, McCoy JV, Dellinger RP, Arnold RC, Rizzuto M, Abate NL, Shapiro NI, Parrillo JE, Hollenberg SM; on behalf of the Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators (2008) Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. doi:10.​1007/​s00134-008-1193-6
2.
Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF (2002) Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 361:1395–1396CrossRef
3.
De Backer D, Hollenberg S, Boerma C, Goedhart P, Büchele G, Ospina-Tascon G, Dobbe I, Ince C (2007) How to evaluate the microcirculation: report of a round table conference. Crit Care 11:R101PubMedCrossRef
4.
De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98–104PubMedCrossRef
Metadata
Title
Microcirculation and multi-organ failure in patients with sepsis
Authors
C. A. den Uil
W. K. Lagrand
J. J. Brugts
P. E. Spronk
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 12/2008
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1272-8

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