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01-08-2007 | Editorial

Understanding high-frequency oscillation: lessons from the animal kingdom

Authors: Niall D. Ferguson, Jesús Villar, Arthur S. Slutsky

Published in: Intensive Care Medicine | Issue 8/2007

Excerpt

Our understanding of the mechanisms and importance of ventilator-induced lung injury (VILI) has advanced over the past three decades, in large part because of carefully conducted animal experiments [1‐4]. The principles derived and knowledge gained from these studies has subsequently been applied and tested in the clinical arena, leading to reductions in mortality in adults with the acute respiratory distress syndrome (ARDS) [5, 6]. While significant progress has been made, mortality of ventilated patients with disease processes, such as ARDS, remains very high, and despite the advances, it is likely that this high mortality is still due partly to VILI. Many experimental and clinical questions related to VILI remain unanswered; one such area is the impact of high-frequency oscillation (HFO) on VILI in ARDS. …

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Title: Understanding high-frequency oscillation: lessons from the animal kingdom
Authors: Niall D. Ferguson
Jesús Villar
Arthur S. Slutsky
Publication date: 01-08-2007
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 8/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0706-z

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Understanding high-frequency oscillation: lessons from the animal kingdom

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