Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 3/2005

01-03-2005 | Correspondence

Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin?

Authors: Jean-Daniel Lalau, Kamel Masmoudi

Published in: Intensive Care Medicine | Issue 3/2005

Login to get access

Excerpt

Sir: Accumulation of the biguanide antihyperglycemic agent metformin has been linked to lactic acidosis, a complication associated with a high mortality rate in critical illness. However, there is mounting evidence that metformin accumulation has no adverse prognostic significance per se and may even be protective in severe pathologies [1]. Here the complete recovery of an elderly woman who presented with prolonged hypoglycemic coma after sulfonylurea intoxication and metformin accumulation provides a new argument for a possible beneficial effect. …
Literature
1.
Lalau J-D, Race J-M (2000) Metformin and lactic acidosis in diabetic humans. Diabetes Obes Metab 2:131–137CrossRef
2.
Wiernsperger NF (2000) Metformin: intrinsic vasculoprotective properties. Diabetes Technol Ther 2:259–272CrossRef
3.
Leverve XM (1999) Energy metabolism in critically ill patients: lactate is a major oxidizable substrate. Curr Opin Clin Nutr Metab Care 2:165–169CrossRef
4.
Erecinska M, Thoresen M, Silver IA (2003) Effects of hypothermia on energy metabolism in mammalian central nervous system. J Cereb Blood Flow Metab 23:513–530CrossRef
5.
UK Prospective Diabetes Study Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854–865CrossRefPubMed
Metadata
Title
Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin?
Authors
Jean-Daniel Lalau
Kamel Masmoudi
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2540-x

Other articles of this Issue 3/2005

Intensive Care Medicine 3/2005 Go to the issue

Experimental

The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock

News

Withdrawal of feeding-tubes from incompetent patients: the Terri Schiavo case raises new issues regarding who decides in end-of-life decision making

Year in Review 2004

Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies

Announcements

March 2005

Correspondence

Procalcitonin in hypoxic brain damage

Original

Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure