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Intensive Care Medicine
Published in: Intensive Care Medicine 7/2004

01-07-2004 | Review

Role of vasopressin in the management of septic shock

Authors: Gökhan M. Mutlu, Phillip Factor

Published in: Intensive Care Medicine | Issue 7/2004

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Abstract

Vasopressin is a potent vasopressor for improving organ perfusion during septic shock. The rationale for the use of vasopressin is its relative deficiency of plasma levels and hypersensitivity to its vasopressor effects during septic shock. Growing evidence suggests that low-dose (<0.04 U/min) vasopressin is safe and effective for the treatment of vasodilatory shock. Although it is being used more frequently, there are no randomized clinical trials comparing vasopressin as a first-line agent to commonly used vasopressors. However, vasopressin causes arterial smooth muscle cell contraction through a non-catecholamine receptor pathway, thus it represents an attractive adjunct to the management of septic shock, especially when catecholamines are ineffective.
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Metadata
Title
Role of vasopressin in the management of septic shock
Authors
Gökhan M. Mutlu
Phillip Factor
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 7/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2283-8

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