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Intensive Care Medicine
Published in: Intensive Care Medicine 5/2004

01-05-2004 | Brief Report

Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units

Authors: Pierre Delanaye, Bernard Lambermont, Jean-Paul Chapelle, Jacques Gielen, Paul Gerard, Georges Rorive

Published in: Intensive Care Medicine | Issue 5/2004

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Abstract

Objective

To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.

Design

Prospective observational study.

Setting

Medical intensive care unit at a university hospital.

Patients and participants

Fourteen patients hospitalised in a medical intensive care unit.

Interventions

Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.

Measurements and results

Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m2 was significantly better than that of creatinine (p<0.05).

Conclusions

Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.
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Metadata
Title
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
Authors
Pierre Delanaye
Bernard Lambermont
Jean-Paul Chapelle
Jacques Gielen
Paul Gerard
Georges Rorive
Publication date
01-05-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 5/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2189-5

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