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01-07-2003 | Review

Red blood cell rheology in sepsis

Authors: M. Piagnerelli, K. Zouaoui Boudjeltia, M. Vanhaeverbeek, J.-L. Vincent

Published in: Intensive Care Medicine | Issue 7/2003

Abstract

Changes in red blood cell (RBC) function can contribute to alterations in microcirculatory blood flow and cellular dysoxia in sepsis. Decreases in RBC and neutrophil deformability impair the passage of these cells through the microcirculation. While the role of leukocytes has been the focus of many studies in sepsis, the role of erythrocyte rheological alterations in this syndrome has only recently been investigated. RBC rheology can be influenced by many factors, including alterations in intracellular calcium and adenosine triphosphate (ATP) concentrations, the effects of nitric oxide, a decrease in some RBC membrane components such as sialic acid, and an increase in others such as 2,3 diphosphoglycerate. Other factors include interactions with white blood cells and their products (reactive oxygen species), or the effects of temperature variations. Understanding the mechanisms of altered RBC rheology in sepsis, and the effects on blood flow and oxygen transport, may lead to improved patient management and reductions in morbidity and mortality.

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Title: Red blood cell rheology in sepsis
Authors: M. Piagnerelli
K. Zouaoui Boudjeltia
M. Vanhaeverbeek
J.-L. Vincent
Publication date: 01-07-2003
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-003-1783-2

At a glance: The STEP trials

Springer Medicine

Red blood cell rheology in sepsis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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