Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Social Psychiatry and Psychiatric Epidemiology
Published in: Social Psychiatry and Psychiatric Epidemiology 1/2017

01-01-2017 | Original Paper

Childhood hyperactivity and mood problems at mid-life: evidence from a prospective birth cohort

Authors: Jenny Stuart-Smith, Anita Thapar, Barbara Maughan, Ajay Thapar, Stephan Collishaw

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 1/2017

Login to get access

Abstract

Purpose

Childhood hyperactivity leads to mental health problems, but it is not known whether there are long-term risks for adult mood problems in unselected population cohorts that extend to mid-life. Aims were to examine links between childhood hyperactivity and mood problems up to age 50 years and to consider confounding factors and gender differences in associations.

Methods

The National Child Development Study (NCDS) is a UK cohort of children born in 1958. Children with (N = 453) and without (N = 9192) pervasive and persistent hyperactivity were followed to age 50. Adult mood was assessed using the Malaise Inventory at ages 23, 33, 42, and 50 years and the CIS-R interview at 45 years.

Results

Childhood hyperactivity predicted low mood at all adult assessments (ES = 0.27–0.45), including after covariate adjustment (childhood adversity, emotional and behavioural problems, and attainment).

Conclusion

Hyperactivity has enduring risk effects on low mood throughout the life course that extend to middle age.
Appendix
Available only for authorised users
Literature
1.
2.
Thapar A, Cooper M, Jefferies R, Stergiakouli E (2012) What causes attention deficit hyperactivity disorder? Arch Dis Child 97:260–265CrossRefPubMed
3.
Cherkasova M, Sulla EM, Dalena KL, Pondé MP, Hechtman L (2013) Developmental course of attention deficit hyperactivity disorder and its predictors. J Can Acad Child Adolesc Psychiatry 22:47–54CrossRefPubMedPubMedCentral
4.
Wilens TE, Biederman J, Spencer TJ (2002) Attention deficit/hyperactivity disorder across the lifespan. Annu Rev Med 53:113–131CrossRefPubMed
5.
Polanczyk GV, Willcott EG, Salum GA, Kieling C, Rohde LA (2014) ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. Int J Epidemiol 43:434–442CrossRefPubMedPubMedCentral
6.
7.
Klein RG, Mannuzza S, Olazagasti MA, Roizen E, Hutchison JA, Lashua EC, Castellanos FX (2012) Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry 69:1295–1303CrossRefPubMedPubMedCentral
8.
Langley K, Fowler T, Ford T, Thapar AK, van den Bree M, Harold G, Owen MJ, O’Donovan MC, Thapar A (2010) Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. Br J Psychiatry 196:235–240CrossRefPubMed
9.
Biederman J, Monuteaux MC, Mick E, Spencer T, Wilens TE, Silva JM, Snyder LE, Faraone SV (2006) Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med 36:167–179CrossRefPubMed
10.
Bussing R, Mason DM, Bell L, Porter P, Garvan C (2010) Adolescent outcomes of childhood attention-deficit/hyperactivity disorder in a diverse community sample. J Am Acad Child Adolesc Psychiatry 49:595–605PubMedPubMedCentral
11.
Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG, Arnold LE (2012) A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Med 10:99CrossRefPubMedPubMedCentral
12.
Able SL, Johnston JA, Adler LA, Swindle RW (2007) Functional and psychosocial impairment in adults with undiagnosed ADHD. Psychol Med 37:97–107CrossRefPubMed
13.
14.
Power C, Elliott J (2006) Cohort profile: 1958 British birth cohort (National Child Development Study). Int J Epidemiol 35:34–41CrossRefPubMed
15.
Rutter M, Tizard J, Whitmore K (1970) Education, health and behaviour. Longman, Green, London
16.
Rodgers B, Pickles A, Power C, Collishaw S, Maughan B (1999) Validity of the Malaise Inventory in general population samples. Soc Psychiatry Psychiatr Epidimiol 34:333–341CrossRef
17.
Takizawa R, Maughan B, Arsenault L (2014) Adult health outcomes of childhood bullying victimization: evidence from a five-decade longitudinal British birth cohort. Am J Psychiatry 171:777–784CrossRefPubMed
18.
Lewis G, Pelosi AJ, Araya R, Dunn G (1992) Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers. Psychol Med 22:465–486CrossRefPubMed
19.
Das-Munschi J, Clark C, Dewey ME, Leavey G, Stansfeld SA, Prince MJ (2013) Does childhood adversity account for poorer mental health and physical health in second-generation Irish people living in Britain? Birth cohort study from Britain (NCDS). BMJ Open 3:e001335CrossRef
20.
Maughan B, Collishaw S, Pickles A (1999) Mild mental retardation: psychosocial functioning in adulthood. Psychol Med 29:351–366CrossRefPubMed
21.
Maughan B, Collishaw S, Stringaris A (2013) Depression in childhood and adolescence. J Can Acad Child Adol Psychiatry 22:35–40
22.
Rutter M, Kim-Cohen J, Maughan B (2006) Continuities and discontinuities in psychopathology between childhood and adult life. J Child Psychol Psychiatry 47:276–295CrossRefPubMed
23.
Stringaris A, Cohen P, Pine DS, Leibenluft E (2009) Adult outcomes of youth irritability: a 20 year prospective community-based study. Am J Psychiatry 166:1048–1054CrossRefPubMedPubMedCentral
24.
Kupfer DJ, Frank E, Phillips MJ (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045–1055CrossRefPubMed
25.
26.
Chang Z, D’Onofrio BM, Quinn PD, Lichtenstein P, Larsson H (2016) Medication for attention-deficit/hyperactivity disorder and risk for depression: a nationwide longitudinal cohort study. Biol Psychiatry. doi:10.​1016/​j.​biopsych.​2016.​02.​018
27.
Sellers R, Maughan B, Pickles A, Thapar A, Collishaw S (2015) Trends in parent- and teacher-rated emotional, conduct and ADHD problems and their impact in prepubertal children in Great Britain: 1999–2008. J Child Psychol Psychiatry 56:49–57CrossRefPubMed
28.
Stergiakouli E, Martin J, Hamshere ML, Langley K, Evans DM, St Pourcain B et al (2015) Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. J Am Acad Child Adolesc Psychiatry 54:322–327CrossRefPubMedPubMedCentral
29.
Collishaw S, Maughan B, Pickles A (2004) Affective problems in adults with mild learning disability: the roles of social disadvantage and ill health. Br J Psychiatry 185:350–351CrossRefPubMed
30.
Young S, Murphy CM, Coghill D (2011) Avoiding the ‘twilight zone’: recommendations for the transition of services from adolescence to adulthood for young people with ADHD. BMC Psychiatry 11:174CrossRefPubMedPubMedCentral
Metadata
Title
Childhood hyperactivity and mood problems at mid-life: evidence from a prospective birth cohort
Authors
Jenny Stuart-Smith
Anita Thapar
Barbara Maughan
Ajay Thapar
Stephan Collishaw
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 1/2017
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-016-1285-5

Other articles of this Issue 1/2017

Social Psychiatry and Psychiatric Epidemiology 1/2017 Go to the issue

Original Paper

Who is going to rescue the rescuers? Post-traumatic stress disorder among rescue workers operating in Greece during the European refugee crisis

Original Paper

The epidemiology of post-traumatic stress disorder in Norway: trauma characteristics and pre-existing psychiatric disorders

Invited Reviews

Mental disorders as networks of problems: a review of recent insights

Original Paper

Mental health of children who work on the streets in Brazil after enrollment in a psychosocial program

Study Protocols and Samples

Facilitating mental health screening of war-torn populations using mobile applications

Original Paper

Education as a social pathway from parental socioeconomic position to depression in late adolescence and early adulthood: a Finnish population-based register study