Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Social Psychiatry and Psychiatric Epidemiology
Published in: Social Psychiatry and Psychiatric Epidemiology 9/2014

01-09-2014 | Editorial

Universal prevention of schizophrenia and surrogate endpoints at population level

Authors: A. Szöke, J. B. Kirkbride, F. Schürhoff

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 9/2014

Login to get access

Abstract

Despite significant progresses in our knowledge of the risk factors for schizophrenia, we still are several steps short of implementing effective prevention strategies. Universal prevention strategies have several theoretical advantages but their implementation has been limited to date by their costs and lack of methods to assess their efficiency. To overcome this limitation, we suggest, based on research from therapeutic trials at individual level, the use of surrogate endpoints (SEs) at population level. We further suggest that subclinical measures of psychosis at population level are good SEs candidates for assessing universal measures for schizophrenia prevention.
Appendix
Available only for authorised users
Literature
1.
Amminger GP, Harris MG, Conus P, Lambert M, Elkins KS, Yuen HP, McGorry PD (2006) Treated incidence of first-episode psychosis in the catchment area of EPPIC between 1997 and 2000. Acta Psychiatr Scand 114:337–345PubMedCrossRef
2.
Boissel JP, Collet JP, Moleur P, Haugh M (1992) Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol 43:235–244PubMedCrossRef
3.
Cuijpers P, Van Straten A, Smit F (2005) Preventing the incidence of new cases of mental disorders: a meta-analytic review. J Nerv Mental Dis 193:119–125CrossRef
4.
Green MJ, Boyle GJ, Raine A (2008) Schizotypal personality models (Chapter 19). In: Boyle GJ, Matthews G, Saklofske DH (eds) The SAGE handbook of personality theory and assessment: Vol 1, Personality theories and models. SAGE Publications Ltd, London
5.
Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO 3rd, Hughes M, Altman D, Buyse M, Galbraith S, Wells G (2007) Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol 34:607–615PubMed
6.
Lesko LJ, Atkinson AJ Jr (2001) Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies. Annu Rev Pharmacol Toxicol 41:347–366PubMedCrossRef
7.
Lin A. (2010) Why Transition is not the whole story: neurocognitive function and risk for psychosis. Thesis for the degree of Doctor of Philosophy. Department of Psychology. The University of Melbourne
8.
Linscott RJ, van Os J (2013) An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychol Med 43(6):1133–1149PubMedCrossRef
9.
Rose G, Day S (1990) The population mean predicts the number of deviant individuals. Br Med J 301:1031–1034CrossRef
10.
Shochet IM, Dadds MR, Holland D, Whitefield K, Harnett PH, Osgarby SM (2001) The efficacy of a universal school-based program to prevent adolescent depression. Journal of Clinical Child Psychology 30:303–315PubMedCrossRef
11.
12.
van Os J, Hanssen M, Bijl RV, Vollebergh W (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Arch Gen Psychiatry 58:663–668PubMedCrossRef
13.
van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 39:179–195PubMedCrossRef
14.
Whittington JE, Huppert FA (1996) Changes in the prevalence of psychiatric disorder in a community are related to changes in the mean level of psychiatric symptoms. Psychol Med 26:1253–1260PubMedCrossRef
15.
Yung AR, Killackey E, Hetrick SE, Parker AG, Schultze-Lutter F, Klosterkoetter J, Purcell R, Mcgorry PD (2007) The prevention of schizophrenia. Int Rev Psychiatry 19:633–646PubMedCrossRef
16.
Yung AR, Yuen HP, Berger G, Francey S, Hung TC, Nelson B, Phillips L, McGorry P (2007) Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophr Bull 33:673–681PubMedCentralPubMedCrossRef
17.
Yung AR, Nelson B, Stanford C, Simmons MB, Cosgrave EM, Killackey E, Phillips LJ, Bechdolf A, Buckby J, McGorry PD (2008) Validation of “prodromal” criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up. Schizophr Res 105:10–17PubMedCrossRef
Metadata
Title
Universal prevention of schizophrenia and surrogate endpoints at population level
Authors
A. Szöke
J. B. Kirkbride
F. Schürhoff
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 9/2014
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-014-0829-9

Other articles of this Issue 9/2014

Social Psychiatry and Psychiatric Epidemiology 9/2014 Go to the issue

Original Paper

Suicidal ideation and attempts among men who inject drugs in Delhi, India: psychological and social risk factors

Original Paper

Patterns of victimization, suicide attempt, and posttraumatic stress disorder in Greenlandic adolescents: a latent class analysis

Original Paper

Sexual orientation disparities in mental health: the moderating role of educational attainment

Original Paper

Risk of suicide according to level of psychiatric treatment: a nationwide nested case–control study

Original Paper

Record-linkage studies of the coexistence of epilepsy and bipolar disorder

Original Paper

Relationship between family quality of life and day occupations of young people with Down syndrome