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Published in: Social Psychiatry and Psychiatric Epidemiology 7/2013

01-07-2013 | Original Paper

Risk factors for onset of multiple or long major depressive episodes versus single and short episodes

Authors: Bauke T. Stegenga, Mirjam I. Geerlings, Francisco Torres-González, Miguel Xavier, Igor Švab, Brenda W. Penninx, Irwin Nazareth, Michael King

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 7/2013

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Abstract

Purpose

Major depressive disorder may vary according to number and duration of episodes. It is unclear whether risk factors for onset of multiple or long episodes of depression (MDE) differ from risk factors for the onset of single and short ones.

Methods

Data were used from a cohort study of 5,256 GP attendees without major depressive disorder at baseline, who were followed up three times (predictD). The numbers and duration of MDE were noted and categorized into no episodes, single and short (≤3 months), and multiple or long (>3 months) episodes at follow-up. Log-binomial regression models were used to calculate relative risks between the groups for 18 risk factors examined at baseline.

Results

165 persons (3 %) had a single and short MDE and 328 (6 %) had multiple or long MDE at follow-up. Lower education, anxiety, problems at work and financial strain significantly increased the risk of multiple or long MDE when compared to single and short MDE. Younger people were at reduced risk of multiple or long MDE.

Conclusions

Our findings suggest that several risk factors can be identified that may help to predict onset of different types of MDE. These factors are easy to assess and may be used in the prevention of depression.
Literature
1.
go back to reference Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442PubMedCrossRef Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442PubMedCrossRef
2.
go back to reference Rybakowski JK, Nawacka D, Kiejna A (2004) One-year course of the first versus multiple episodes of depression—Polish naturalistic study. Eur Psychiatry 19(5):258–263PubMedCrossRef Rybakowski JK, Nawacka D, Kiejna A (2004) One-year course of the first versus multiple episodes of depression—Polish naturalistic study. Eur Psychiatry 19(5):258–263PubMedCrossRef
3.
go back to reference Lewinsohn PM, Allen NB, Seeley JR, Gotlib IH (1999) First onset versus recurrence of depression: differential processes of psychosocial risk. J Abnorm Psychol 108(3):483–489PubMedCrossRef Lewinsohn PM, Allen NB, Seeley JR, Gotlib IH (1999) First onset versus recurrence of depression: differential processes of psychosocial risk. J Abnorm Psychol 108(3):483–489PubMedCrossRef
4.
go back to reference Solomon DA, Keller MB, Leon AC, Mueller TI, Lavori PW, Shea MT et al (2000) Multiple recurrences of major depressive disorder. Am J Psychiatry 157(2):229–233PubMedCrossRef Solomon DA, Keller MB, Leon AC, Mueller TI, Lavori PW, Shea MT et al (2000) Multiple recurrences of major depressive disorder. Am J Psychiatry 157(2):229–233PubMedCrossRef
5.
go back to reference Roca M, Armengol S, Garcia-Garcia M, Rodriguez-Bayon A, Ballesta I, Serrano MJ et al (2011) Clinical differences between first and recurrent episodes in depressive patients. Compr Psychiatry 52(1):26–32PubMedCrossRef Roca M, Armengol S, Garcia-Garcia M, Rodriguez-Bayon A, Ballesta I, Serrano MJ et al (2011) Clinical differences between first and recurrent episodes in depressive patients. Compr Psychiatry 52(1):26–32PubMedCrossRef
6.
go back to reference Klein DN, Glenn CR, Kosty DB, Seeley JR, Rohde P, Lewinsohn PM (2012) Predictors of first lifetime onset of major depressive disorder in young adulthood. J Abnorm Psychol. doi:10.1037/a0029567 Klein DN, Glenn CR, Kosty DB, Seeley JR, Rohde P, Lewinsohn PM (2012) Predictors of first lifetime onset of major depressive disorder in young adulthood. J Abnorm Psychol. doi:10.​1037/​a0029567
7.
go back to reference Penninx BW, Nolen WA, Lamers F, Zitman FG, Smit JH, Spinhoven P et al (2011) Two-year course of depressive and anxiety disorders: results from the Netherlands Study of Depression and Anxiety (NESDA). J Affect Disord 133(1–2):76–85PubMedCrossRef Penninx BW, Nolen WA, Lamers F, Zitman FG, Smit JH, Spinhoven P et al (2011) Two-year course of depressive and anxiety disorders: results from the Netherlands Study of Depression and Anxiety (NESDA). J Affect Disord 133(1–2):76–85PubMedCrossRef
8.
go back to reference Eaton WW, Shao H, Nestadt G, Lee HB, Bienvenu OJ, Zandi P (2008) Population-based study of first onset and chronicity in major depressive disorder. Arch Gen Psychiatry 65(5):513–520PubMedCrossRef Eaton WW, Shao H, Nestadt G, Lee HB, Bienvenu OJ, Zandi P (2008) Population-based study of first onset and chronicity in major depressive disorder. Arch Gen Psychiatry 65(5):513–520PubMedCrossRef
9.
go back to reference Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2002) Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Br J Psychiatry 181:208–213PubMedCrossRef Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2002) Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Br J Psychiatry 181:208–213PubMedCrossRef
10.
go back to reference van Weel-Baumgarten EM, Schers HJ, van den Bosch WJ, van den Hoogen HJ, Zitman FG (2000) Long-term follow-up of depression among patients in the community and in family practice settings. A systematic review. J Fam Pract 49(12):1113–1120PubMed van Weel-Baumgarten EM, Schers HJ, van den Bosch WJ, van den Hoogen HJ, Zitman FG (2000) Long-term follow-up of depression among patients in the community and in family practice settings. A systematic review. J Fam Pract 49(12):1113–1120PubMed
11.
go back to reference Mattisson C, Bogren M, Horstmann V, Munk-Jorgensen P, Nettelbladt P (2007) The long-term course of depressive disorders in the Lundby Study. Psychol Med 37(6):883–891PubMedCrossRef Mattisson C, Bogren M, Horstmann V, Munk-Jorgensen P, Nettelbladt P (2007) The long-term course of depressive disorders in the Lundby Study. Psychol Med 37(6):883–891PubMedCrossRef
12.
go back to reference Rhebergen D, Beekman AT, Graaf R, Nolen WA, Spijker J, Hoogendijk WJ et al (2009) The three-year naturalistic course of major depressive disorder, dysthymic disorder and double depression. J Affect Disord 115(3):450–459PubMedCrossRef Rhebergen D, Beekman AT, Graaf R, Nolen WA, Spijker J, Hoogendijk WJ et al (2009) The three-year naturalistic course of major depressive disorder, dysthymic disorder and double depression. J Affect Disord 115(3):450–459PubMedCrossRef
13.
go back to reference Dowrick C, Shiels C, Page H, Ayuso-Mateos JL, Casey P, Dalgard OS et al (2009) Predicting long-term recovery from depression in community settings in Western Europe: evidence from ODIN. Soc Psychiatry Psychiatr Epidemiol 46(2):119–126PubMedCrossRef Dowrick C, Shiels C, Page H, Ayuso-Mateos JL, Casey P, Dalgard OS et al (2009) Predicting long-term recovery from depression in community settings in Western Europe: evidence from ODIN. Soc Psychiatry Psychiatr Epidemiol 46(2):119–126PubMedCrossRef
14.
go back to reference Stegenga BT, Kamphuis MH, King M, Nazareth I, Geerlings MI (2010) The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study. Soc Psychiatry Psychiatr Epidemiol 47(1):87–95PubMedCrossRef Stegenga BT, Kamphuis MH, King M, Nazareth I, Geerlings MI (2010) The natural course and outcome of major depressive disorder in primary care: the PREDICT-NL study. Soc Psychiatry Psychiatr Epidemiol 47(1):87–95PubMedCrossRef
15.
go back to reference Melartin TK, Rytsala HJ, Leskela US, Lestela-Mielonen PS, Sokero TP, Isometsa ET (2004) Severity and comorbidity predict episode duration and recurrence of DSM-IV major depressive disorder. J Clin Psychiatry 65(6):810–819PubMedCrossRef Melartin TK, Rytsala HJ, Leskela US, Lestela-Mielonen PS, Sokero TP, Isometsa ET (2004) Severity and comorbidity predict episode duration and recurrence of DSM-IV major depressive disorder. J Clin Psychiatry 65(6):810–819PubMedCrossRef
16.
go back to reference Ustun TB, Kessler RC (2002) Global burden of depressive disorders: the issue of duration. Br J Psychiatry 181:181–183PubMedCrossRef Ustun TB, Kessler RC (2002) Global burden of depressive disorders: the issue of duration. Br J Psychiatry 181:181–183PubMedCrossRef
17.
go back to reference de Jonge P, Conradi HJ, Kaptein KI, Bockting CL, Korf J, Ormel J (2010) Duration of subsequent episodes and periods of recovery in recurrent major depression. J Affect Disord 125(1–3):141–145PubMedCrossRef de Jonge P, Conradi HJ, Kaptein KI, Bockting CL, Korf J, Ormel J (2010) Duration of subsequent episodes and periods of recovery in recurrent major depression. J Affect Disord 125(1–3):141–145PubMedCrossRef
18.
go back to reference Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2004) Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). J Affect Disord 81(3):231–240PubMedCrossRef Spijker J, de Graaf R, Bijl RV, Beekman AT, Ormel J, Nolen WA (2004) Determinants of persistence of major depressive episodes in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). J Affect Disord 81(3):231–240PubMedCrossRef
19.
go back to reference Wilhelm K, Parker G, Whurst-Savellis J, Asghari A (1999) Psychological predictors of single and recurrent major depressive episodes. J Affect Disord 54(1–2):139–147PubMedCrossRef Wilhelm K, Parker G, Whurst-Savellis J, Asghari A (1999) Psychological predictors of single and recurrent major depressive episodes. J Affect Disord 54(1–2):139–147PubMedCrossRef
20.
go back to reference King M, Weich S, Torres F, Svab I, Maaroos H, Neeleman J et al (2006) Prediction of depression in European general practice attendees: the PREDICT study. BMC Public Health 6(1):6PubMedCrossRef King M, Weich S, Torres F, Svab I, Maaroos H, Neeleman J et al (2006) Prediction of depression in European general practice attendees: the PREDICT study. BMC Public Health 6(1):6PubMedCrossRef
21.
go back to reference King M, Bottomley C, Bellon-Saameno JA, Torres-Gonzalez F, Svab I, Rifel J et al (2011) An international risk prediction algorithm for the onset of generalized anxiety and panic syndromes in general practice attendees: predictA. Psychol Med 6:1–15 King M, Bottomley C, Bellon-Saameno JA, Torres-Gonzalez F, Svab I, Rifel J et al (2011) An international risk prediction algorithm for the onset of generalized anxiety and panic syndromes in general practice attendees: predictA. Psychol Med 6:1–15
22.
go back to reference King M, Walker C, Levy G, Bottomley C, Royston P, Weich S et al (2008) Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the predictD study. Arch Gen Psychiatry 65(12):1368–1376PubMedCrossRef King M, Walker C, Levy G, Bottomley C, Royston P, Weich S et al (2008) Development and validation of an international risk prediction algorithm for episodes of major depression in general practice attendees: the predictD study. Arch Gen Psychiatry 65(12):1368–1376PubMedCrossRef
23.
go back to reference King M, Nazareth I, Levy G, Walker C, Morris R, Weich S et al (2008) Prevalence of common mental disorders in general practice attendees across Europe. Br J Psychiatry 192(5):362–367PubMedCrossRef King M, Nazareth I, Levy G, Walker C, Morris R, Weich S et al (2008) Prevalence of common mental disorders in general practice attendees across Europe. Br J Psychiatry 192(5):362–367PubMedCrossRef
24.
go back to reference Bottomley C, Nazareth I, Torres-Gonzalez F, Svab I, Maaroos HI, Geerlings MI et al (2010) Comparison of risk factors for the onset and maintenance of depression. Br J Psychiatry 196(1):13–17PubMedCrossRef Bottomley C, Nazareth I, Torres-Gonzalez F, Svab I, Maaroos HI, Geerlings MI et al (2010) Comparison of risk factors for the onset and maintenance of depression. Br J Psychiatry 196(1):13–17PubMedCrossRef
25.
go back to reference Stegenga BT, Nazareth I, Torres-Gonzalez F, Xavier M, Svab I, Geerlings MI et al (2011) Depression, anxiety and physical function: exploring the strength of causality. J Epidemiol Community Health 66(7):e25PubMedCrossRef Stegenga BT, Nazareth I, Torres-Gonzalez F, Xavier M, Svab I, Geerlings MI et al (2011) Depression, anxiety and physical function: exploring the strength of causality. J Epidemiol Community Health 66(7):e25PubMedCrossRef
26.
go back to reference Stegenga BT, Nazareth I, Grobbee DE, Torres-Gonzalez F, Svab I, Maaroos HI et al (2012) Recent life events pose greatest risk for onset of major depressive disorder during mid-life. J Affect Disord 136(3):505–513PubMedCrossRef Stegenga BT, Nazareth I, Grobbee DE, Torres-Gonzalez F, Svab I, Maaroos HI et al (2012) Recent life events pose greatest risk for onset of major depressive disorder during mid-life. J Affect Disord 136(3):505–513PubMedCrossRef
27.
go back to reference Stegenga BT, King M, Grobbee DE, Torres-Gonzalez F, Svab I, Maaroos HI et al (2012) Differential impact of risk factors for women and men on the risk of major depressive disorder. Ann Epidemiol 22(6):388–396PubMedCrossRef Stegenga BT, King M, Grobbee DE, Torres-Gonzalez F, Svab I, Maaroos HI et al (2012) Differential impact of risk factors for women and men on the risk of major depressive disorder. Ann Epidemiol 22(6):388–396PubMedCrossRef
28.
go back to reference World Health Organisation (1997) Composite International Diagnostic Interview (CIDI). Version 2.1 WHO, Geneva (computer program) World Health Organisation (1997) Composite International Diagnostic Interview (CIDI). Version 2.1 WHO, Geneva (computer program)
29.
go back to reference American Psychiatric Association A (1994) Diagnostic and Statistical Manual of Mental Disorders DSM-IV. American Psychiatric Publishing, Arlington American Psychiatric Association A (1994) Diagnostic and Statistical Manual of Mental Disorders DSM-IV. American Psychiatric Publishing, Arlington
30.
go back to reference Lamers F, Rhebergen D, Merikangas KR, de Jonge P, Beekman AT, Penninx BW (2012) Stability and transitions of depressive subtypes over a 2 year follow-up. Psychol Med 17:1–11 Lamers F, Rhebergen D, Merikangas KR, de Jonge P, Beekman AT, Penninx BW (2012) Stability and transitions of depressive subtypes over a 2 year follow-up. Psychol Med 17:1–11
31.
go back to reference Weich S (2001) Risk Factors for Common Mental Disorders in Primary Care. University of Cambridge, Cambridge Weich S (2001) Risk Factors for Common Mental Disorders in Primary Care. University of Cambridge, Cambridge
32.
go back to reference Karasek RA, Theorell T (1990) Healthy work: stress, productivity, and the reconstruction of working life (basic books) Karasek RA, Theorell T (1990) Healthy work: stress, productivity, and the reconstruction of working life (basic books)
33.
go back to reference Weich S, Lewis G (1998) Poverty, unemployment, and common mental disorders: population based cohort study. BMJ 317(7151):115–119PubMedCrossRef Weich S, Lewis G (1998) Poverty, unemployment, and common mental disorders: population based cohort study. BMJ 317(7151):115–119PubMedCrossRef
34.
go back to reference Sproston K, Primatesta P (2003) Health survey for England 2002: a survey carried out on behalf of the Department of Health. The Stationery Office, London Sproston K, Primatesta P (2003) Health survey for England 2002: a survey carried out on behalf of the Department of Health. The Stationery Office, London
36.
go back to reference Qureshi N, Bethea J, Modell B, Brennan P, Papageorgiou A, Raeburn S et al (2005) Collecting genetic information in primary care: evaluating a new family history tool. Fam Pract 22(6):663–669PubMedCrossRef Qureshi N, Bethea J, Modell B, Brennan P, Papageorgiou A, Raeburn S et al (2005) Collecting genetic information in primary care: evaluating a new family history tool. Fam Pract 22(6):663–669PubMedCrossRef
37.
go back to reference Spitzer RL, Kroenke K, Williams JB (1999) Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire. JAMA 282(18):1737–1744PubMedCrossRef Spitzer RL, Kroenke K, Williams JB (1999) Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient health questionnaire. JAMA 282(18):1737–1744PubMedCrossRef
38.
go back to reference Jenkinson C, Layte R, Jenkinson D, Lawrence K, Petersen S, Paice C et al (1997) A shorter form health survey: can the SF-12 replicate results from the SF-36 in longitudinal studies? J Public Health Med 19(2):179–186PubMedCrossRef Jenkinson C, Layte R, Jenkinson D, Lawrence K, Petersen S, Paice C et al (1997) A shorter form health survey: can the SF-12 replicate results from the SF-36 in longitudinal studies? J Public Health Med 19(2):179–186PubMedCrossRef
39.
go back to reference Fink LA, Bernstein D, Handelsman L, Foote J, Lovejoy M (1995) Initial reliability and validity of the childhood trauma interview: a new multidimensional measure of childhood interpersonal trauma. Am J Psychiatry 152(9):1329–1335PubMed Fink LA, Bernstein D, Handelsman L, Foote J, Lovejoy M (1995) Initial reliability and validity of the childhood trauma interview: a new multidimensional measure of childhood interpersonal trauma. Am J Psychiatry 152(9):1329–1335PubMed
40.
go back to reference Brugha T, Bebbington P, Tennant C, Hurry J (1985) The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 15(1):189–194PubMedCrossRef Brugha T, Bebbington P, Tennant C, Hurry J (1985) The list of threatening experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med 15(1):189–194PubMedCrossRef
41.
go back to reference Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al (2008) The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatr Res 17(3):121–140PubMedCrossRef Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al (2008) The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatr Res 17(3):121–140PubMedCrossRef
42.
go back to reference Blizzard L, Hosmer DW (2006) Parameter estimation and goodness-of-fit in log binomial regression. Biom J 48(1):5–22PubMedCrossRef Blizzard L, Hosmer DW (2006) Parameter estimation and goodness-of-fit in log binomial regression. Biom J 48(1):5–22PubMedCrossRef
43.
go back to reference Robbins AS, Chao SY, Fonseca VP (2002) What’s the relative risk? a method to directly estimate risk ratios in cohort studies of common outcomes. Ann Epidemiol 12(7):452–454PubMedCrossRef Robbins AS, Chao SY, Fonseca VP (2002) What’s the relative risk? a method to directly estimate risk ratios in cohort studies of common outcomes. Ann Epidemiol 12(7):452–454PubMedCrossRef
44.
go back to reference Barros AJ, Hirakata VN (2003) Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol 20(3):21CrossRef Barros AJ, Hirakata VN (2003) Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol 20(3):21CrossRef
45.
go back to reference McNutt LA, Wu C, Xue X, Hafner JP (2003) Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol 157(10):940–943PubMedCrossRef McNutt LA, Wu C, Xue X, Hafner JP (2003) Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol 157(10):940–943PubMedCrossRef
46.
go back to reference Zou G (2004) A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 159(7):702–706PubMedCrossRef Zou G (2004) A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 159(7):702–706PubMedCrossRef
47.
go back to reference Katon W, Lin E, Von Korff M, Bush T, Walker E, Simon G et al (1994) The predictors of persistence of depression in primary care. J Affect Disord 31(2):81–90PubMedCrossRef Katon W, Lin E, Von Korff M, Bush T, Walker E, Simon G et al (1994) The predictors of persistence of depression in primary care. J Affect Disord 31(2):81–90PubMedCrossRef
48.
go back to reference Barkow K, Maier W, Ustun TB, Gansicke M, Wittchen HU, Heun R (2003) Risk factors for depression at 12 month follow-up in adult primary health care patients with major depression: an international prospective study. J Affect Disord 76(1–3):157–169PubMedCrossRef Barkow K, Maier W, Ustun TB, Gansicke M, Wittchen HU, Heun R (2003) Risk factors for depression at 12 month follow-up in adult primary health care patients with major depression: an international prospective study. J Affect Disord 76(1–3):157–169PubMedCrossRef
49.
go back to reference Poutanen O, Mattila A, Seppala NH, Groth L, Koivisto AM, Salokangas RK (2007) Seven-year outcome of depression in primary and psychiatric outpatient care: results of the TADEP (Tampere Depression) II Study. Nord J Psychiatry 61(1):62–70PubMedCrossRef Poutanen O, Mattila A, Seppala NH, Groth L, Koivisto AM, Salokangas RK (2007) Seven-year outcome of depression in primary and psychiatric outpatient care: results of the TADEP (Tampere Depression) II Study. Nord J Psychiatry 61(1):62–70PubMedCrossRef
50.
go back to reference Gilchrist G, Gunn J (2007) Observational studies of depression in primary care: what do we know? BMC Fam Pract 8:28PubMedCrossRef Gilchrist G, Gunn J (2007) Observational studies of depression in primary care: what do we know? BMC Fam Pract 8:28PubMedCrossRef
51.
go back to reference Conradi HJ, de Jonge P, Ormel J (2007) Prediction of the three-year course of recurrent depression in primary care patients: Different risk factors for different outcomes. J Affect Disord 105(1–3):267–271PubMed Conradi HJ, de Jonge P, Ormel J (2007) Prediction of the three-year course of recurrent depression in primary care patients: Different risk factors for different outcomes. J Affect Disord 105(1–3):267–271PubMed
52.
go back to reference Limosin F, Loze JY, Zylberman-Bouhassira M, Schmidt ME, Perrin E, Rouillon F (2004) The course of depressive illness in general practice. Can J Psychiatry 49(2):119–123PubMed Limosin F, Loze JY, Zylberman-Bouhassira M, Schmidt ME, Perrin E, Rouillon F (2004) The course of depressive illness in general practice. Can J Psychiatry 49(2):119–123PubMed
53.
go back to reference Vuorilehto MS, Melartin TK, Isometsa ET (2009) Course and outcome of depressive disorders in primary care: a prospective 18 month study. Psychol Med 2:1–11 Vuorilehto MS, Melartin TK, Isometsa ET (2009) Course and outcome of depressive disorders in primary care: a prospective 18 month study. Psychol Med 2:1–11
54.
go back to reference Meltzer H, Bebbington P, Dennis MS, Jenkins R, McManus S, Brugha TS (2012) Feelings of loneliness among adults with mental disorder. Soc Psychiatry Psychiatr Epidemiol. doi:10.1007/s00127-012-0515-8 Meltzer H, Bebbington P, Dennis MS, Jenkins R, McManus S, Brugha TS (2012) Feelings of loneliness among adults with mental disorder. Soc Psychiatry Psychiatr Epidemiol. doi:10.​1007/​s00127-012-0515-8
55.
go back to reference de Graaf R, Tuithof M, van Dorsselaer S, ten Have M (2012) Comparing the effects on work performance of mental and physical disorders. Soc Psychiatry Psychiatr Epidemiol 47(11):1873–1883PubMedCrossRef de Graaf R, Tuithof M, van Dorsselaer S, ten Have M (2012) Comparing the effects on work performance of mental and physical disorders. Soc Psychiatry Psychiatr Epidemiol 47(11):1873–1883PubMedCrossRef
56.
go back to reference Carder M, Turner S, McNamee R, Agius R (2009) Work-related mental ill-health and ‘stress’ in the UK (2002–05). Occup Med (Lond) 59(8):539–544CrossRef Carder M, Turner S, McNamee R, Agius R (2009) Work-related mental ill-health and ‘stress’ in the UK (2002–05). Occup Med (Lond) 59(8):539–544CrossRef
57.
go back to reference Kessler RC, Birnbaum HG, Shahly V, Bromet E, Hwang I, McLaughlin KA et al (2010) Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative. Depress Anxiety 27(4):351–364PubMedCrossRef Kessler RC, Birnbaum HG, Shahly V, Bromet E, Hwang I, McLaughlin KA et al (2010) Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative. Depress Anxiety 27(4):351–364PubMedCrossRef
58.
go back to reference Kessler RC, Birnbaum H, Bromet E, Hwang I, Sampson N, Shahly V (2010) Age differences in major depression: results from the National Comorbidity Survey Replication (NCS-R). Psychol Med 40(2):225–237PubMedCrossRef Kessler RC, Birnbaum H, Bromet E, Hwang I, Sampson N, Shahly V (2010) Age differences in major depression: results from the National Comorbidity Survey Replication (NCS-R). Psychol Med 40(2):225–237PubMedCrossRef
Metadata
Title
Risk factors for onset of multiple or long major depressive episodes versus single and short episodes
Authors
Bauke T. Stegenga
Mirjam I. Geerlings
Francisco Torres-González
Miguel Xavier
Igor Švab
Brenda W. Penninx
Irwin Nazareth
Michael King
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 7/2013
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-012-0626-2

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