Published in:
01-05-2018 | Letter
Can insulin response patterns predict metabolic disease risk in individuals with normal glucose tolerance? Reply to Crofts CAP, Brookler K, Henderson G [letter]
Published in: Diabetologia | Issue 5/2018
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To the Editor: We would like to thank Crofts et al [1] for their positive and constructive comments regarding our article [2]. The main reason why we have not explored insulin response in the Danish Inter99 cohort using the latent class trajectory approach is fairly technical. Serum insulin values are usually log-transformed before analysing them as continuous outcomes because of their skewed distributions. In our study, this would mean we would model a piecewise-linear trajectory on the log-scale (Fig. 1a), which results in a rather unrealistic shape when transformed back to the original scale (Fig. 1b). Imposing the peak at 30 min is already a big restriction; therefore, we did not want to put this further constraint on the shape of the insulin response curve.
Fig. 1
Serum insulin trajectory on the (a) logarithmic and (b) original scale. The curves represent a fictional participant for the purpose of demonstration
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