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Published in: Diabetologia 4/2017

01-04-2017 | Letter

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Authors: Martha L. Campbell-Thompson, Mark A. Atkinson, Alexandra E. Butler, Ben N. Giepmans, Matthias G. von Herrath, Heikki Hyöty, Thomas W. Kay, Noel G. Morgan, Alvin C. Powers, Alberto Pugliese, Sarah J. Richardson, Peter A. In’t Veld

Published in: Diabetologia | Issue 4/2017

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Excerpt

To the Editor: Lundberg et al [1] propose a ‘revised’ definition of insulitis in human type 1 diabetes to replace the current consensus guidelines published in 2013 [2]. The authors of this letter, being affiliated with the initial authoritative report, disagree and offer unanimous affirmation and continuing support for the 2013 guidelines.
Literature
1.
go back to reference Lundberg M, Seiron P, Ingvast S, Korsgren O, Skog O (2017) Insulitis in human diabetes: a histological evaluation of donor pancreases. Diabetologia 60:346–353 Lundberg M, Seiron P, Ingvast S, Korsgren O, Skog O (2017) Insulitis in human diabetes: a histological evaluation of donor pancreases. Diabetologia 60:346–353
2.
go back to reference Campbell-Thompson ML, Atkinson MA, Butler AE et al (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56:2541–2543CrossRefPubMed Campbell-Thompson ML, Atkinson MA, Butler AE et al (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56:2541–2543CrossRefPubMed
3.
go back to reference Campbell-Thompson M, Fu A, Kaddis JS et al (2016) Insulitis and β-cell mass in the natural history of type 1 diabetes. Diabetes 65:719–731CrossRefPubMed Campbell-Thompson M, Fu A, Kaddis JS et al (2016) Insulitis and β-cell mass in the natural history of type 1 diabetes. Diabetes 65:719–731CrossRefPubMed
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go back to reference Leete P, Willcox A, Krogvold L et al (2016) Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes 65:1362–1369CrossRefPubMed Leete P, Willcox A, Krogvold L et al (2016) Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes 65:1362–1369CrossRefPubMed
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go back to reference Coppieters KT, Dotta F, Amirian N et al (2012) Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 209:51–60CrossRefPubMedPubMedCentral Coppieters KT, Dotta F, Amirian N et al (2012) Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 209:51–60CrossRefPubMedPubMedCentral
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go back to reference Ewald N, Kaufmann C, Raspe A, Kloer HU, Bretzel RG, Hardt PD (2012) Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes Metab Res Rev 28:338–342CrossRefPubMed Ewald N, Kaufmann C, Raspe A, Kloer HU, Bretzel RG, Hardt PD (2012) Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes Metab Res Rev 28:338–342CrossRefPubMed
Metadata
Title
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Authors
Martha L. Campbell-Thompson
Mark A. Atkinson
Alexandra E. Butler
Ben N. Giepmans
Matthias G. von Herrath
Heikki Hyöty
Thomas W. Kay
Noel G. Morgan
Alvin C. Powers
Alberto Pugliese
Sarah J. Richardson
Peter A. In’t Veld
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 4/2017
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-016-4195-x

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