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01-07-2016 | Commentary

The power of numbers

Authors: Marco Dauriz, James B. Meigs

Published in: Diabetologia | Issue 7/2016

Excerpt

The study of human genetic variation represents a major chapter in the history of modern medicine and still holds the fascinating promise of identifying the genetic architecture of a large number of disease traits [1, 2]. This is particularly relevant nowadays, in light of the prospective rising trends in the global incidence and prevalence of type 2 diabetes [3]. However, the non-communicable diseases, such as type 2 diabetes, carry a considerable burden of complexity, as a result of the combination of genetic, epigenetic and environmental risk factors [4], which complicate the understanding of type 2 diabetes genetic background and its potential clinical transferability in terms of prognostic and preventive rules or potentially novel drug targets. …

The 1,000 Genomes Project Consortium (2015) A global reference for human genetic variation. Nature 526:68–74CrossRef

Pearson TA, Manolio TA (2008) How to interpret a genome-wide association study. JAMA 299:1335–1344CrossRefPubMed

World Health Organization (2015) World health statistics 2015. WHO Press, Geneva

Prasad RB, Groop L (2015) Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) 6:87–123

Zhang K, Calabrese P, Nordborg M, Sun F (2002) Haplotype block structure and its applications to association studies: power and study designs. Am J Hum Genet 71:1386–1394CrossRefPubMedPubMedCentral

Zuk O, Schaffner SF, Samocha K et al (2014) Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A 111:E455–E464CrossRefPubMedPubMedCentral

Hivert MF, Vassy JL, Meigs JB (2014) Susceptibility to type 2 diabetes mellitus—from genes to prevention. Nat Rev Endocrinol 10:198–205CrossRefPubMedPubMedCentral

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium et al (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 46:234–244CrossRef

Gan W, Walters RG, Holmes MV et al (2016) Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank. Diabetologia. doi:10.1007/s00125-016-3920-9 PubMed

10.

Vassy JL, Hivert MF, Porneala B et al (2014) Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes 63:2172–2182CrossRefPubMedPubMedCentral

11.

ENCODE Project Consortium et al (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489:57–74CrossRef

12.

Edwards SL, Beesley J, French JD, Dunning AM (2013) Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet 93:779–797CrossRefPubMedPubMedCentral

Title: The power of numbers
Authors: Marco Dauriz
James B. Meigs
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: Diabetologia / Issue 7/2016
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-016-3962-z

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