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01-09-2016 | Mini-review

Sources of beta cells inside the pancreas

Authors: Sofie De Groef, Willem Staels, Naomi Van Gassen, Marie Lemper, Yixing Yuchi, Mozhdeh Sojoodi, Leen Bussche, Yves Heremans, Gunter Leuckx, Nico De Leu, Mark Van de Casteele, Luc Baeyens, Harry Heimberg

Published in: Diabetologia | Issue 9/2016

Abstract

The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto)immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the ‘Can we make a better beta cell?’ symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: 10.1007/s00125-016-3892-9, and by Heiko Lickert and colleagues, DOI: 10.1007/s00125-016-3949-9) and a commentary by the Session Chair, Shanta Persaud (DOI: 10.1007/s00125-016-3870-2).

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Title: Sources of beta cells inside the pancreas
Authors: Sofie De Groef
Willem Staels
Naomi Van Gassen
Marie Lemper
Yixing Yuchi
Mozhdeh Sojoodi
Leen Bussche
Yves Heremans
Gunter Leuckx
Nico De Leu
Mark Van de Casteele
Luc Baeyens
Harry Heimberg
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Diabetologia / Issue 9/2016
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-016-3879-6

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