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Diabetologia
Published in: Diabetologia 7/2014

01-07-2014 | Letter

Autoantibodies and type 1 diabetes: are we still in the cave of an ancient myth?

Author: Alfonso Galderisi

Published in: Diabetologia | Issue 7/2014

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Excerpt

To the Editor: Autoimmunity has been an undisputed boundary line between type 1 diabetes and other forms of diabetes, including type 2 and MODY, observed in paediatric patients [1], although recent evidence should lead us to reconsider this boundary carefully. …
Literature
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Wolfsdorf J, Craig ME, Daneman D et al (2009) ISPAD Clinical Practice Consensus Guidelines 2009 Compendium. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes 10(Suppl 12):118–133PubMedCrossRef
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Donath MY, Hess C, Palmer E (2014) What is the role of autoimmunity in type 1 diabetes? A clinical perspective. Diabetologia 57:653–655PubMedCrossRef
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Krogvold L, Edwin B, Buanes T et al (2014) Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study. Diabetologia 57:841–843PubMedCrossRef
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Brooks-Worrell B, Narla R, Palmer JP (2013) Islet autoimmunity in phenotypic type 2 diabetes patients. Diabetes Obes Metab 15(Suppl 3):137–140PubMedCrossRef
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d'Annunzio G, Marchi M, Aloi C, Salina A, Lugani F, Lorini R (2013) Hyperglycaemia and β-cell antibodies: is it always pre-type 1 diabetes? Diabetes Res Clin Pract 100:e20–e22PubMedCrossRef
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Irgens HU, Molnes J, Johansson BB et al (2013) Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. Diabetologia 56:1512–1519PubMedCrossRef
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Jaeger C, Hatziagelaki E, Petzoldt R et al (2001) Comparative analysis of organ-specific autoantibodies and celiac disease-associated antibodies in type 1 diabetic patients, their first degree relatives, and healthy control subjects. Diabetes Care 24:27–32PubMedCrossRef
9.
Murphy R, Ellard S, Hattersley AT (2008) Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 4:200–213PubMedCrossRef
Metadata
Title
Autoantibodies and type 1 diabetes: are we still in the cave of an ancient myth?
Author
Alfonso Galderisi
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 7/2014
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-014-3261-5

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