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Diabetologia
Published in: Diabetologia 7/2013

01-07-2013 | Commentary

Islet encapsulation: advances and obstacles

Author: G. C. Weir

Published in: Diabetologia | Issue 7/2013

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Abstract

It has been known for decades that encapsulation can protect transplanted islets from immune destruction in rodents, but it has proved difficult to extend this success to large animals and humans. A new study in this issue by Jacobs-Tulleneers-Thevissen et al (doi: 10.​1007/​s00125-013-2906-0) advances the field by showing that human islets contained in alginate capsules can function very well, not only in the peritoneal cavity of mice, but also in a human with type 1 diabetes. Many obstacles must still be overcome, but this technology has the potential to safely protect transplanted beta cells from autoimmunity and allorejection.
Literature
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Metadata
Title
Islet encapsulation: advances and obstacles
Author
G. C. Weir
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 7/2013
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-013-2921-1

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