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Open Access 01-01-2012 | Commentary

Antidepressant drug use and future diabetes risk

Authors: M. Kivimäki, G. D. Batty

Published in: Diabetologia | Issue 1/2012

Excerpt

Debate around the side effects of antidepressants, one of the most prescribed groups of drugs worldwide [1], continues. First there was a concern that antidepressant medication may, with rather tragic irony, increase suicide risk. Then, meta-analyses suggested that there was no significant benefit of antidepressants over placebo in treating patients with minor depression [2]. The most recent controversy relates to a series of studies, including one in the present issue of Diabetologia, suggesting that long-term use of antidepressants might predispose individuals to type 2 diabetes [3‐5]. …

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Brown LC, Majumdar SR, Johnson JA (2008) Type of antidepressant therapy and risk of type 2 diabetes in people with depression. Diab Res Clin Pract 79:61–67CrossRef

Andersohn F, Schade R, Suissa S, Garbe E (2009) Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry 166:591–598PubMedCrossRef

Kivimäki M, Hamer M, Batty GD et al (2010) Antidepressant medication use, weight gain and risk of type 2 diabetes mellitus: a population-based study. Diabetes Care 33:2611–2616PubMedCrossRef

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (2008) Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 358:252–260PubMedCrossRef

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Pan A, Sun Q, Okereke OI et al (2011) Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults. Diabetologia. doi:10.1007/s00125-011-2268-49

Campayo A, de Jonge P, Roy JF, Saz P et al (2010) Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry 167:580–588PubMedCrossRef

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Knol MJ, Geerlings MI, Egberts AC, Gorter KJ, Grobbee DE, Heerdink ER (2007) No increased incidence of diabetes in antidepressant users. Int Clin Psychopharmacol 22:382–386PubMedCrossRef

11.

Kivimäki M, Batty GD, Jokela M et al (2011) Antidepressant medication use and risk of hyperglycaemia and diabetes mellitus—a non-causal association? Biol Psychiatry. doi:10.1016/j.biopsych.2011.07.008

12.

Rubin RR, Ma Y, Peyrot M et al (2010) Antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. Diabetes Care 33:2549–2551PubMedCrossRef

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Centers for Disease Control and Prevention (2011) National Diabetes Fact Sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta

Title: Antidepressant drug use and future diabetes risk
Authors: M. Kivimäki
G. D. Batty
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Diabetologia / Issue 1/2012
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-011-2360-9

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