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Diabetologia
Published in: Diabetologia 8/2011

01-08-2011 | Commentary

The influence of sex and puberty on the progression of diabetic nephropathy and retinopathy

Author: J. N. Harvey

Published in: Diabetologia | Issue 8/2011

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Excerpt

With the current insulins, treatment regimens, monitoring systems and devices, severe hyper- and hypoglycaemia can largely be avoided. Increasingly, it is prevention of the long term complications of diabetes that has become the focus of modern diabetes care, especially in childhood onset diabetes, where the lifetime potential for morbidity and excess mortality is greatest. Achieving a better understanding of predisposing factors and mechanisms involved is therefore important. …
Literature
1.
Harjutsalo V, Maric C, Forsblom C, Thorn L, Waden J, Groop PH; on behalf of the FinnDiane Study Group (2011) Sex-related differences in the long-term risk of microvascular complications by age at onset of type 1 diabetes. Diabetologia. doi:10.​1007/​s00125-011-2144-2
2.
Mollsten A, Svensson M, Waernbaum I et al (2010) Cumulative risk, age at onset, and sex-specific differences for developing end-stage renal disease in young patients with type 1 diabetes. Diabetes 59:1803–1808PubMedCrossRef
3.
Harvey JN, Allagoa B (2004) The long-term renal and retinal outcome of childhood-onset type 1 diabetes. Diabet Med 21:26–31PubMedCrossRef
4.
Amin R, Schultz C, Ong K et al (2003) Low IGF-1 and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects. Diabetes Care 26:1456–1461PubMedCrossRef
5.
Maric C, Forsblom C, Thorn L, Waden J, Groop PH (2010) Association between testosterone, estradiol and sex hormone binding globulin levels in men with type 1 diabetes with nephropathy. Steroids 75:772–778PubMedCrossRef
6.
Haffner SM, Klein R, Dunn JF, Moss SE, Klein BEK (1990) Increased testosterone in type 1 diabetic subjects with severe retinopathy. Ophthalmology 97:1270–1274PubMed
7.
Haffner SM, Klein R, Moss SE, Klein BEK (1993) Sex hormones and the incidence of severe retinopathy in male subjects with type 1 diabetes. Ophthalmology 100:1782–1786PubMed
8.
Writing team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2003) Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy. The Epidemiology of Diabetes Interventions and Complications (EDIC) Study. JAMA 290:2159–2167CrossRef
9.
Krowleski AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR (1985) The changing natural history of nephropathy in type 1 diabetes. Am J Med 78:785–794CrossRef
10.
Schultz CJ, Neil HAW, Dalton RN, Dunger DB (2000) Risk of nephropathy can be detected before the onset of microalbuminuria during the early years after diagnosis of type 1 diabetes. Diabetes Care 23:1811–1842PubMedCrossRef
11.
Barkai L, Vamosi I, Lukacs K (1998) Enhanced progression of urinary albumin excretion in IDDM during puberty. Diabetes Care 21:1019–1023PubMedCrossRef
12.
Janner M, Knill SE, Diem P, Zuppinger KA, Mullis PE (1994) Persistent microalbuminuria in adolescents with type 1 (insulin-dependent) diabetes mellitus is associated to early rather than late puberty. Eur J Pediatr 153:403–408PubMedCrossRef
13.
Ellis EN, Warady BA, Wood EG et al (1997) Renal structural–functional relationships in early diabetes mellitus. Pediatr Nephrol 11:584–591PubMedCrossRef
14.
Bangstad HJ, Osterby R, Rudberg S, Hartmann A, Brabrand K, Hanssen KF (2002) Kidney function and glomerulopathy over 8 years in young patients with type 1 (insulin-dependent) diabetes mellitus and microalbuminuria. Diabetologia 45:253–261PubMedCrossRef
15.
Hostetter TH, Rennke HG, Brenner BM (1982) The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72:375–380PubMedCrossRef
16.
Holl RW, Lang GE, Grabert M, Heinze E, Lang GK, Debatin KM (1998) Diabetic retinopathy in pediatric patients with type 1 diabetes: effect of diabetes duration, prepubertal and pubertal onset of diabetes, and metabolic control. J Pediatr 138:790–794
17.
Bacci S, de Cosmo S, Garruba M et al (2000) Role of insulin-like growth factor (IGF)-1 in the modulation of renal haemodynamics in type 1 diabetic patients. Diabetologia 43:922–926PubMedCrossRef
18.
Neugarten J, Kasiske B, Silbiger SR, Nyengaard JR (2002) Effects of sex on renal structure. Nephron 90:139–144PubMedCrossRef
19.
Lane PH (2002) Diabetic kidney disease: impact of puberty. Am J Physiol Renal Physiol 283:F589–F600PubMed
20.
Miller JA, Anacta LA, Cattran DC (1999) Impact of gender on the renal response to angiotensin II. Kidney Int 55:278–285PubMedCrossRef
21.
Cherney DZ, Sochett EB, Miller JA (2005) Gender differences in renal responses to hyperglycaemia and angiotensin converting enzyme inhibition in diabetes. Kidney Int 68:1722–1728PubMedCrossRef
22.
Lane P, Snelling D, Hollman A, Langer W (2001) Puberty permits increased expression of renal transforming growth factor-β1 in experimental diabetes. Pediatr Nephrol 16:1033–1039PubMedCrossRef
23.
24.
Zhang X, Youhong J, Jackson EK, Tofovic SP (2007) 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF rats. J Cardiovasc Pharmacol 49:56–63PubMedCrossRef
25.
Guccione M, Silbiger S, Lei J, Silbiger SR (2001) Estradiol up regulates mesangial cell MMP-2 activity via transcription factor AP-2. Am J Physiol 282:F1–F6
26.
Hadjadj S, Gourdy P, Zaoui P et al (2007) Effect of raloxifene—a selective oestrogen receptor modulator—on kidney function in post-menopausal women with type 2 diabetes: results from a randomized, placebo-controlled pilot trial. Diabet Med 24:906–910PubMedCrossRef
27.
O’Hagan M, Harvey JN (2010) Glycaemic control in children with type 1 diabetes in Wales. Diabetes Care 33:1724–1726PubMedCrossRef
Metadata
Title
The influence of sex and puberty on the progression of diabetic nephropathy and retinopathy
Author
J. N. Harvey
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 8/2011
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-011-2185-6

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