Published in:
Open Access
01-06-2008 | Research Letter
Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus
Authors:
M. Nieuwdorp, M. Vergeer, R. J. Bisoendial, J. op ‘t Roodt, H. Levels, R. S. Birjmohun, J. A. Kuivenhoven, R. Basser, T. J. Rabelink, J. J. P. Kastelein, E. S. G. Stroes
Published in:
Diabetologia
|
Issue 6/2008
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Excerpt
To the Editor: HDL-cholesterol is inversely correlated with cardiovascular events in all major epidemiological studies [
1]. HDL-increasing strategies have demonstrated that HDL-cholesterol increase is associated with decreased cardiovascular risk in high-risk individuals such as patients with type 2 diabetes [
2]. Endothelial dysfunction, a hallmark of type 2 diabetes patients, has been shown to predict future cardiovascular events [
3]. Therefore, we investigated the effect of reconstituted HDL (rHDL) on endothelial function measured both acutely (4 h after infusion) and 7 days after infusion in type 2 diabetes patients. Control volunteers were measured only at baseline and 4 h after infusion. …
