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Diabetologia
Published in: Diabetologia 7/2007

01-07-2007 | Article

A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996

Authors: N. Lammi, O. Taskinen, E. Moltchanova, I-L. Notkola, J. G. Eriksson, J. Tuomilehto, M. Karvonen

Published in: Diabetologia | Issue 7/2007

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Abstract

Aims/hypothesis

The aim of this study was to examine the incidence and trends of type 1 and type 2 diabetes in the 15–39 year-old population between 1992 and 1996 in Finland.

Subjects and methods

Data on the nationwide incidence of diabetes were obtained from four data sources: standardised reports from diabetes nurses, the Finnish National Hospital Discharge Register, the Drug Reimbursement Register and the Drug Prescription Register. The inclusion criterion was consistency in the diagnosis of diabetes across at least two data sources. The sex- and age-specific incidence was calculated for 5-year age groups, both for type 1 and type 2 diabetes. The effects of age, sex and year of diagnosis were assessed by fitting the linear regression model to the incidence data.

Results

Between 1992 and 1996 the age-adjusted incidence of type 1 diabetes among 15–39 year olds was 15.9 per 100,000/year. The incidence was highest among the 15–19 year olds and decreased with age. Conversely, the incidence of type 2 diabetes was very low among 15–19 year olds and increased with age. The total age-adjusted incidence of type 2 diabetes among 15–39 year olds was 11.8 per 100,000/year. The average annual increase in the incidence of type 2 diabetes was 7.9% (95% CI 3.7–12.2%).

Conclusions/interpretation

The age at which the Finnish population is at risk of type 1 diabetes extends into young adulthood. The rapid increase in the incidence of type 2 diabetes in the young adult population is a current public health problem.
Literature
1.
Genuth S, Alberti KG, Bennet P et al; The Expert Committee on the Diagnosis and Classification on Diabetes Mellitus (2003) Follow-up report on the diagnosis and classification of diabetes mellitus. Diabetes Care 26:3160–3167CrossRefPubMed
2.
Tuomilehto J, Zimmet P, Mackay IR et al (1994) Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 343:1383–1385CrossRefPubMed
3.
American Diabetes Association (2006) Diagnosis and classification of diabetes mellitus. Diabetes Care 29(Suppl 1):S43–S48
4.
Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J (2000) Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23:1516–1526CrossRefPubMed
5.
DIAMOND Project Group (2006) Incidence and trends of childhood type 1 diabetes worldwide 1990–1999. Diabet Med 23:857–866CrossRef
6.
Karvonen M, Pitkäniemi J, Tuomilehto J; The Finnish Childhood Diabetes Registry Group (1999) The onset age of type 1 diabetes in Finnish Children has become younger. Diabetes Care 22:1066–1070CrossRefPubMed
7.
Melton LJ, Palumbo PJ, Chu CP (1983) Incidence of diabetes mellitus by clinical type. Diabetes Care 6:75–86CrossRefPubMed
8.
Lorenzen T, Pociot F, Hougaard P, Nerup J (1994) Long-term risk of IDDM in first-degree relatives of patients with IDDM. Diabetologia 37:321–327CrossRefPubMed
9.
10.
Borg H, Arnqvist HJ, Bjork E et al (2003) Evaluation of the new ADA and WHO criteria for classification of diabetes mellitus in young adult people (15–34 yrs) in the Diabetes Incidence Study in Sweden (DISS). Diabetologia 46:173–181CrossRefPubMed
11.
Feltbower RG, McKinney PA, Campbell FM, Stephenson CR, Bodansky HJ (2003) Type 2 and other forms of diabetes in 0–30 year olds: a hospital based study in Leeds, UK. Arch Dis Child 88:676–679CrossRefPubMed
12.
Gungor N, Hannon T, Libman I, Bacha F, Arslanian S (2005) Type 2 diabetes mellitus in youth: the complete picture to date. Pediatr Clin North Am 52:1579–1609CrossRefPubMed
13.
Caillat-Zucman S, Garchon HJ, Timsit J et al (1992) Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest 90:2242–2250PubMedCrossRef
14.
Blohme G, Nystrom L, Arnqvist HJ et al (1992) Male predominance of type 1 (insulin-dependent) diabetes mellitus in young adults: results from a 5-year prospective nationwide study of the 15–34-year age group in Sweden. Diabetologia 35:56–62CrossRefPubMed
15.
Vandewalle CL, Falorni A, Svanholm S, Lernmark A, Pipeleers DG, Gorus FK (1995) High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry. J Clin Endocrinol Metab 80:846–851CrossRefPubMed
16.
Vandewalle CL, Falorni A, Lenrnmark A et al (1997) Associations of GAD65- and IA-2-autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry. Diabetes Care 20:1547–1552CrossRefPubMed
17.
Kyvik KO, Nystrom L, Gorus F et al (2004) The epidemiology of type 1 diabetes mellitus is not the same in young adults as in children. Diabetologia 47:377–384CrossRefPubMed
18.
The DECODE Study Group (2003) Age and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 26:61–69CrossRef
19.
The DECODA Study Group (2003) Age and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care 26:1770–1780CrossRef
20.
Libman I, Arslanian SA (1999) Type II diabetes mellitus: no longer just adults. Pediatr Ann 28:589–593PubMed
21.
Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22:345–354CrossRefPubMed
22.
Fagot-Campagna A, Pettitt DJ, Engelgau MM et al (2000) Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr 136:664–672CrossRefPubMed
23.
Owen KR, Stride A, Ellard S, Hattersley AT (2003) Etiological investigation of diabetes in young adults presenting with apparent type 2 diabetes. Diabetes Care 26:2088–2093CrossRefPubMed
24.
LaPorte RE, McCarty D, Bruno C, Tajima N, Baba S (1993) Counting diabetes in the next millennium. Application of capture-recapture technology. Diabetes Care 16:528–534CrossRefPubMed
25.
Anderson RN, Rosenberg HM (1998) Age standardization of death rates: implementation of the year 2000 standard. Natl Vital Stat Rep 47:1–16, 20
26.
Rothman KJ, Greenland S (1998) Modern epidemiology, 2nd edn. Lippincott-Raven, Philadelphia, pp 237–239
27.
Pajunen P, Koukkunen H, Ketonen M et al (2005) The validity of the Finnish hospital discharge register and causes of death register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil 12:132–137CrossRefPubMed
28.
Mahonen M, Miettinen H, Pyorälä K, Molarius A, Salomaa V, Kuulasmaa K (1995) Hospital discharge register data in the assessment of trends in acute myocardial infarction. FINMONICA AMI Register Study Team. Ann Med 27:547–554PubMed
29.
Ylihärsilä H, Lindström J, Eriksson JG et al (2005) Prevalence of diabetes and impaired glucose regulation in 45- to 64-year-old individuals in three areas of Finland. Diabet Med 22:88–91CrossRefPubMed
30.
Bushhouse SA, Goetz FC, Jacobs DR Jr et al (1992) C-peptide response to meal challenge in nondiabetic and diabetic adults living in Wadena, Minnesota. Diabetes Care 15:1335–1347CrossRefPubMed
31.
Aguilera E, Casamitjana R, Ercilla G, Oriola J, Gomis R, Conget I (2004) Adult-onset atypical (type 1) diabetes: additional insights and differences with type 1A diabetes in a European Mediterranean population. Diabetes Care 27:1108–1114CrossRefPubMed
32.
Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, Kuller LH, Trucco M (2000) Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes. Diabetes 49:32–38CrossRefPubMed
33.
34.
Gilliam LK, Brooks-Worrell BM, Palmer JP, Greenbaum CJ, Pihoker C (2005) Autoimmunity and clinical course in children with type 1, type 2, and type 1.5 diabetes. J Autoimmun 25:244–250CrossRefPubMed
35.
Donath MY, Ehses JA (2006) Type 1, type 1.5, and type 2 diabetes: NOD the diabetes we thought it was. Proc Natl Acad Sci USA 103:12217–12218CrossRefPubMed
36.
Tuomilehto-Wolf E, Tuomilehto J, Hitman GA et al (1993). Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA-region. BMJ 307:155–159PubMedCrossRef
37.
38.
Rytkönen M (2004) Geographical study on childhood type 1 diabetes mellitus (T1DM) in Finland. Oulu University Press, Oulu
39.
Bruno G, Cerutti F, Merletti F et al (2005) Residual beta-cell function and male/female ratio are higher in incident young adults than in children: the registry of type 1 diabetes of the province of Turin, Italy, 1984–2000. Diabetes Care 28:312–317CrossRefPubMed
40.
Kadiki OA, Reddy MR, Marzouk AA (1996) Incidence of insulin-dependent diabetes (IDDM) and non-insulin-dependent diabetes (NIDDM) (0–34 years at onset) in Benghazi, Libya. Diabetes Res Clin Pract 32:165–173CrossRefPubMed
41.
Wiegand S, Maikowski U, Blankenstein O, Biebermann H, Tarnow P, Gruters A (2004) Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity—a problem that is no longer restricted to minority groups. Eur J Endocrinol 151:199–206CrossRefPubMed
42.
Koopman RJ, Mainous AG, Diaz VA, Geesey ME (2005) Changes in age at diagnosis of type 2 diabetes mellitus in the United States, 1988 to 2000. Ann Fam Med 3:60–63CrossRefPubMed
43.
SEARCH for Diabetes in Youth Study Group (2006) The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for diabetes in youth study. Pediatrics 118:1510–1518CrossRef
44.
45.
Kautiainen S, Rimpelä A, Vikat A, Virtanen SM (2002) Secular trends in overweight and obesity among Finnish adolescents in 1977–1999. Int J Obes Relat Metab Disord 26:544–552CrossRefPubMed
46.
Mikkola I, Keinänen-Kiukaanniemi S, Laakso M et al (2007) Metabolic syndrome in connection with BMI in young Finnish male adults. Diabetes Res Clin Pract 76:404–409CrossRefPubMed
47.
Santtila M, Kyröläinen H, Vasankari T et al (2006) Physical fitness profiles in young Finnish men during the years 1975–2004. Med Sci Sports Exerc 38:1990–1994CrossRefPubMed
48.
Lindstrom J, Ilanne-Parikka P, Peltonen M et al (2006) Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet 368:1673–1679CrossRefPubMed
Metadata
Title
A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996
Authors
N. Lammi
O. Taskinen
E. Moltchanova
I-L. Notkola
J. G. Eriksson
J. Tuomilehto
M. Karvonen
Publication date
01-07-2007
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 7/2007
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-007-0690-4

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