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Diabetologia
Published in: Diabetologia 10/2006

01-10-2006 | Article

The effect of diabetes and stroke at baseline and during follow-up on stroke mortality

Authors: G. Hu, P. Jousilahti, C. Sarti, R. Antikainen, J. Tuomilehto

Published in: Diabetologia | Issue 10/2006

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Abstract

Aims/hypothesis

The aim of this study was to compare the magnitude of the effect of diabetes and stroke at baseline and during follow-up on risk of stroke mortality.

Materials and methods

Study cohorts included 25,155 Finnish men and 26,423 women aged 25–74 years. Data on diabetes and stroke history at baseline, their incidence during follow-up, and stroke death were obtained from national registers.

Results

During a mean follow-up of 18.9 years, 838 stroke deaths were recorded. In the baseline study, hazard ratios (HRs) for stroke mortality were 5.26 for men with prior diabetes only, 4.76 for men with prior stroke only, and 13.4 for men with both prior diabetes and stroke compared with men without diabetes and stroke at baseline and during follow-up. In women, the corresponding hazard ratios were 7.29, 5.27 and 5.52, respectively. When only diabetes and stroke status during the follow-up were considered, the hazard ratios for stroke mortality were 1.41 for men and 1.56 for women with incident diabetes only, 5.62 for men and 5.58 for women with incident stroke only, and 5.59 for men and 4.48 for women with both incident diabetes and stroke compared with men and women without diabetes and stroke at baseline and during follow-up.

Conclusions/interpretation

Diabetes and stroke, present either at baseline or during follow-up, markedly increase the risk of stroke death. Prior stroke at baseline carries a similar risk of stroke mortality as prior diabetes. There is a greater risk of stroke mortality associated with incident stroke during follow-up than with incident diabetes.
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Metadata
Title
The effect of diabetes and stroke at baseline and during follow-up on stroke mortality
Authors
G. Hu
P. Jousilahti
C. Sarti
R. Antikainen
J. Tuomilehto
Publication date
01-10-2006
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 10/2006
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0378-1

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