Published in:
01-05-2003 | Observation
The polymorphism Gly574Ser in the transcription factor HNF-1α is not a marker of adult-onset ketosis-prone atypical diabetes in Afro-Caribbean patients
Authors:
Dr. F. Mauvais-Jarvis, P. Boudou, E. Sobngwi, J. P. Riveline, J. P. Kevorkian, J. M. Villette, R. Porcher, P. Vexiau, J. F. Gautier
Published in:
Diabetologia
|
Issue 5/2003
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Excerpt
To the Editor: Type 1B diabetes or ketosis-prone atypical diabetes (KPAD) is a subtype of diabetes mostly described in patients of sub-Saharan African ancestry and characterized by insulin dependence at the time of presentation, without immunological markers seen in typical Type 1A diabetes (T1D), and frequently followed by absence of insulin requirements as in the case of Type 2 diabetes (T2D) [
1,
2,
3]. The subsequent clinical course of KPAD, which could represent up to 12% of the sub-Saharan African diabetic population, is characterized by an alternance of near normoglycaemic remissions and relapses of insulin dependence without precipitating illness [
3,
4]. Despite metabolic studies showing a beta-cell insulin secretory defect, no large genetic characterization has focused on this clinical subtype of diabetes. …
