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European Journal of Trauma and Emergency Surgery
Published in: European Journal of Trauma and Emergency Surgery 3/2022

Open Access 03-02-2021 | Central Nervous System Trauma | Review Article

Extracellular vesicles as mediators and markers of acute organ injury: current concepts

Authors: Birte Weber, Niklas Franz, Ingo Marzi, Dirk Henrich, Liudmila Leppik

Published in: European Journal of Trauma and Emergency Surgery | Issue 3/2022

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Abstract

Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in close proximity as well as distant cells in healthy and disease organisms. miRNAs and proteins transferred by EVs play biological roles in maintaining normal organ structure and function under physiological conditions. In pathological conditions, EVs change the miRNAs and protein cargo composition, mediating or suppressing the injury consequences. Therefore, incorporating EVs with their unique protein and miRNAs signature into the list of promising new biomarkers is a logical next step. In this review, we discuss the general characteristics and technical aspects of EVs isolation and characterization. We discuss results of recent in vitro, in vivo, and patients study describing the role of EVs in different inflammatory diseases and traumatic organ injuries. miRNAs and protein signature of EVs found in patients with acute organ injury are also debated.
Literature
1.
Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, Abbasi-Kangevari M, Abbastabar H, Abd-Allah F, Abdelalim A, Abdollahi M. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet (Lond, Engl). 2020;396(10258):1204–22.CrossRef
2.
Xu W, Song Y. Biomarkers for patients with trauma associated acute respiratory distress syndrome. Mil Med Res. 2017;4:25.PubMedPubMedCentral
3.
4.
Chargaff E, West R. The biological significance of the thromboplastic protein of blood. J Biol Chem. 1946;166(1):189–97.PubMedCrossRef
5.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.PubMedPubMedCentralCrossRef
6.
Lässer C, Jang SC, Lötvall J. Subpopulations of extracellular vesicles and their therapeutic potential. Mol Aspects Med. 2018;60:1–14.PubMedCrossRef
7.
Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, et al. Extracellular vesicles in liver pathobiology. Small particles with big impact. Hepatology. 2016;64(6):2219–33.PubMedCrossRef
8.
9.
Kuravi SJ, Yates CM, Foster M, Harrison P, Hazeldine J, et al. Changes in the pattern of plasma extracellular vesicles after severe trauma. PLoS ONE. 2017;12(8):e0183640.PubMedPubMedCentralCrossRef
10.
Yáñez-Mó M, Siljander PR-M, Andreu Z, Zavec AB, Borràs FE, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066.PubMedCrossRef
11.
Crescitelli R, Lässer C, Szabó TG, Kittel A, Eldh M, et al. Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles. 2013;2:20677.CrossRef
12.
13.
Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478).
14.
15.
Gonda DD, Akers JC, Kim R, Kalkanis SN, Hochberg FH, et al. Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles. Neurosurgery. 2013;72(4):501–10.PubMedCrossRef
16.
Jeppesen DK, Hvam ML, Primdahl-Bengtson B, Boysen AT, Whitehead B, et al. Comparative analysis of discrete exosome fractions obtained by differential centrifugation. J Extracell Vesicles. 2014;3:25011.PubMedCrossRef
17.
Yu L-L, Zhu J, Liu J-X, Jiang F, Ni W-K, et al. A comparison of traditional and novel methods for the separation of exosomes from human samples. Biomed Res Int. 2018;2018:3634563.PubMedPubMedCentralCrossRef
18.
Livshits MA, Livshts MA, Khomyakova E, Evtushenko EG, Lazarev VN, et al. Isolation of exosomes by differential centrifugation: theoretical analysis of a commonly used protocol. Sci Rep. 2015;5:17319.PubMedCrossRef
19.
Zhang M, Jin K, Gao L, Zhang Z, Li F, et al. Methods and technologies for exosome isolation and characterization. Small Methods. 2018;2(9):1800021.CrossRef
20.
21.
Witwer KW, Buzás EI, Bemis LT, Bora A, Lässer C, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. 2013;2:20360.CrossRef
22.
Lobb RJ, Becker M, Wen SW, Wong CSF, Wiegmans AP, et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles. 2015;4:27031.PubMedCrossRef
23.
Merchant ML, Powell DW, Wilkey DW, Cummins TD, Deegens JK, et al. Microfiltration isolation of human urinary exosomes for characterization by MS. Proteomics Clin Appl. 2010;4(1):84–96.PubMedCrossRef
24.
Cheruvanky A, Zhou H, Pisitkun T, Kopp JB, Knepper MA, et al. Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator. Am J Physiol Renal Physiol. 2007;292(5):F1657–61.PubMedCrossRef
25.
Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, et al. Concise review: developing best-practice models for the therapeutic use of extracellular vesicles. Stem Cells Transl Med. 2017;6(8):1730–9.PubMedPubMedCentralCrossRef
26.
Alvarez ML, Khosroheidari M, Kanchi Ravi R, DiStefano JK. Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers. Kidney Int. 2012;82(9):1024–32.PubMedCrossRef
27.
Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells. 2019;8(7):727.PubMedCentralCrossRef
28.
Hong CS, Muller L, Boyiadzis M, Whiteside TL. Isolation and characterization of CD34+ blast-derived exosomes in acute myeloid leukemia. PLoS ONE. 2014;9(8):e103310.PubMedPubMedCentralCrossRef
29.
Zeringer E, Barta T, Li M. Vlassov AV (2015) Strategies for isolation of exosomes. Cold Spring Harbor Protoc. 2015;4:319–23.
30.
31.
van Deun J, Mestdagh P, Sormunen R, Cocquyt V, Vermaelen K, et al. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling. J Extracell Vesicles. 2014;3:24858.CrossRef
32.
Dragovic RA, Gardiner C, Brooks AS, Tannetta DS, Ferguson DJP, et al. Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomed Nanotechnol Biol Med. 2011;7(6):780–8.CrossRef
33.
Filipe V, Hawe A, Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res. 2010;27(5):796–810.PubMedPubMedCentralCrossRef
34.
Palmieri V, Lucchetti D, Gatto I, Maiorana A, Marcantoni M, et al. Dynamic light scattering for the characterization and counting of extracellular vesicles: a powerful noninvasive tool. J Nanopart Res. 2014;16(9):1–8.CrossRef
35.
Frisken BJ. Revisiting the method of cumulants for the analysis of dynamic light-scattering data. Appl Opt. 2001;40(24):4087–91.PubMedCrossRef
36.
Gurunathan S, Kang M-H, Jeyaraj M, Qasim M, Kim J-H. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8(4):807.CrossRef
37.
Ko J, Carpenter E, Issadore D. Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices. Analyst. 2016;141(2):450–60.PubMedPubMedCentralCrossRef
38.
Szatanek R, Baj-Krzyworzeka M, Zimoch J, Lekka M, Siedlar M, et al. The methods of choice for extracellular vesicles (EVs) characterization. Int J Mol Sci. 2017;18(6):1153.PubMedCentralCrossRef
39.
Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, et al. Hospital incidence and mortality rates of sepsis. Deutsches Arzteblatt Int. 2016;113(10):159–66.
40.
Moreira J. Severe sepsis and septic shock. N Engl J Med. 2013;369(21):2062–3.CrossRef
41.
Huber-Lang M. Sepsis nach polytrauma. Trauma Berufskrankh. 2018;20(S1):73–6.CrossRef
42.
Eriksson M, Nelson D, Nordgren A, Larsson A. Increased platelet microvesicle formation is associated with mortality in a porcine model of endotoxemia. Acta Anaesthesiol Scand. 1998;42(5):551–7.PubMedCrossRef
43.
Janiszewski M, Do Carmo AO, Pedro MA, Silva E, Knobel E, et al. Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity. A novel vascular redox pathway. Crit Care Med. 2004;32(3):818–25.PubMedCrossRef
44.
Matsumoto H, Yamakawa K, Ogura H, Koh T, Matsumoto N, et al. Clinical significance of tissue factor and CD13 double-positive microparticles in sirs patients with trauma and severe sepsis. Shock. 2017;47(4):409–15.PubMedCrossRef
45.
Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, et al. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med. 2014;6(1):27–42.PubMedCrossRef
46.
Keerthikumar S, Chisanga D, Ariyaratne D, Al Saffar H, Anand S, et al. ExoCarta. A web-based compendium of exosomal cargo. J Mol Biol. 2016;428(4):688–92.PubMedCrossRef
47.
Lee H, Abston E, Zhang D, Rai A, Jin Y. Extracellular vesicle. An emerging mediator of intercellular crosstalk in lung inflammation and injury. Front Immunol. 2018;9:924.PubMedPubMedCentralCrossRef
48.
Curry N, Raja A, Beavis J, Stanworth S, Harrison P. Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality. J Extracell Vesicles. 2014;3:25625.PubMedCrossRef
49.
Unnewehr H, Rittirsch D, Sarma JV, Zetoune F, Flierl MA, et al. Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (Baltimore, MD:1950). 2013;190(8):4215–25.CrossRef
50.
Xu J, Feng Y, Jeyaram A, Jay SM, Zou L, et al. Circulating plasma extracellular vesicles from septic mice induce inflammation via MicroRNA- and TLR7-dependent mechanisms. J Immunol (Baltimore, Md:1950). 2018;201(11):3392–400.CrossRef
51.
Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, et al. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun. 2015;6:7321.PubMedCrossRef
52.
Momen-Heravi F, Bala S, Bukong T, Szabo G. Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. Nanomed Nanotechnol Biol Med. 2014;10(7):1517–27.CrossRef
53.
Liu J, Shi K, Chen M, Xu L, Hong J, et al. Elevated miR-155 expression induces immunosuppression via CD39(+) regulatory T-cells in sepsis patient. Int J Infect Dis. 2015;40:135–41.PubMedCrossRef
54.
Wang X, Gu H, Qin D, Yang L, Huang W, et al. Exosomal miR-223 contributes to mesenchymal stem cell-elicited cardioprotection in polymicrobial sepsis. Sci Rep. 2015;5:13721.PubMedPubMedCentralCrossRef
55.
Song Y, Dou H, Li X, Zhao X, Li Y, et al. Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1β-primed mesenchymal stem cells against sepsis. Stem Cells (Dayton, Ohio). 2017;35(5):1208–21.CrossRef
56.
Ti D, Hao H, Tong C, Liu J, Dong L, et al. LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b. J Transl Med. 2015;13:308.PubMedPubMedCentralCrossRef
57.
Majdan M, Plancikova D, Brazinova A, Rusnak M, Nieboer D, et al. Epidemiology of traumatic brain injuries in Europe: a cross-sectional analysis. Lancet Public Health. 2016;1(2):e76–83.PubMedCrossRef
58.
Adekoya N, Thurman DJ, White DD, Webb KW. Surveillance for traumatic brain injury deaths—United States, 1989–1998. Morb Mortal Wkly Rep Surveill Summ (Washington, DC:2002). 2002;51(10):1–14.
59.
Maas AIR, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol. 2008;7(8):728–41.PubMedCrossRef
60.
Brooks JC, Strauss DJ, Shavelle RM, Paculdo DR, Hammond FM, et al. Long-term disability and survival in traumatic brain injury: results from the National Institute on Disability and Rehabilitation Research Model Systems. Arch Phys Med Rehabil. 2013;94(11):2203–9.PubMedCrossRef
61.
Panaro MA, Benameur T, Porro C. Extracellular vesicles miRNA cargo for microglia polarization in traumatic brain injury. Biomolecules. 2020;10(6):901.PubMedCentralCrossRef
62.
Lachenal G, Pernet-Gallay K, Chivet M, Hemming FJ, Belly A, et al. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity. Mol Cell Neurosci. 2011;46(2):409–18.PubMedCrossRef
63.
Dickens AM, Tovar-Y-Romo LB, Yoo S-W, Trout AL, Bae M et al. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Sci Signaling. 2017;10(473).
64.
Hooper C, Sainz-Fuertes R, Lynham S, Hye A, Killick R, et al. Wnt3a induces exosome secretion from primary cultured rat microglia. BMC Neurosci. 2012;13:144.PubMedPubMedCentralCrossRef
65.
Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11(7):e1001604.PubMedPubMedCentralCrossRef
66.
Chen CC, Liu L, Ma F, Wong CW, Guo XE, et al. Elucidation of exosome migration across the blood-brain barrier model in vitro. Cell Mol Bioeng. 2016;9(4):509–29.PubMedCrossRef
67.
Xu B, Zhang Y, Du X-F, Li J, Zi H-X, et al. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Res. 2017;27(7):882–97.PubMedPubMedCentralCrossRef
68.
Gayen M, Bhomia M, Balakathiresan N, Knollmann-Ritschel B. Exosomal MicroRNAs released by activated astrocytes as potential neuroinflammatory biomarkers. Int J Mol Sci. 2020;21(7):2312.PubMedCentralCrossRef
69.
Ko J, Hemphill M, Yang Z, Sewell E, Na YJ, et al. Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles. Lab Chip. 2018;18(23):3617–30.PubMedPubMedCentralCrossRef
70.
Lei P, Li Y, Chen X, Yang S, Zhang J. Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. Brain Res. 2009;1284:191–201.PubMedCrossRef
71.
Harrison EB, Hochfelder CG, Lamberty BG, Meays BM, Morsey BM, et al. Traumatic brain injury increases levels of miR-21 in extracellular vesicles. Implications for neuroinflammation. FEBS Open Bio. 2016;6(8):835–46.PubMedPubMedCentralCrossRef
72.
Wang P, Ma H, Zhang Y, Zeng R, Yu J, et al. Plasma Exosome-derived MicroRNAs as novel biomarkers of traumatic brain injury in rats. Int J Med Sci. 2020;17(4):437–48.PubMedPubMedCentralCrossRef
73.
Gill J, Mustapic M, Diaz-Arrastia R, Lange R, Gulyani S, et al. Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel. Brain Inj. 2018;32(10):1277–84.PubMedPubMedCentral
74.
Kenney K, Qu B-X, Lai C, Devoto C, Motamedi V, et al. Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury. Brain Inj. 2018;32(10):1276–84.PubMedCrossRef
75.
Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, et al. Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019;33(4):5082–8.PubMedPubMedCentralCrossRef
76.
Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, et al. Preliminary study of plasma exosomal tau as a potential biomarker for chronic traumatic encephalopathy. J Alzheimer’s Dis JAD. 2016;51(4):1099–109.CrossRef
77.
Nekludov M, Bellander B-M, Gryth D, Wallen H, Mobarrez F. Brain-derived microparticles in patients with severe isolated TBI. Brain Inj. 2017;31(13–14):1856–62.PubMedCrossRef
78.
Peskind ER, Kraemer B, Zhang J. Biofluid biomarkers of mild traumatic brain injury: whither plasma tau. JAMA Neurol. 2015;72(10):1103–5.PubMedCrossRef
79.
Ni H, Yang S, Siaw-Debrah F, Hu J, Wu K, et al. Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury. Front Neurosci. 2019;13:14.PubMedPubMedCentralCrossRef
80.
Xu H, Jia Z, Ma K, Zhang J, Dai C, et al. Protective effect of BMSCs-derived exosomes mediated by BDNF on TBI via miR-216a-5p. Med Sci Monit. 2020;26:e920855.PubMedPubMedCentral
81.
Zhang Y, Chopp M, Meng Y, Katakowski M, Xin H, et al. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg. 2015;122(4):856–67.PubMedPubMedCentralCrossRef
82.
Liu W, Rong Y, Wang J, Zhou Z, Ge X, et al. Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization. J Neuroinflamm. 2020;17(1):47.CrossRef
83.
Sybrandy KC, Cramer MJM, Burgersdijk C. Diagnosing cardiac contusion: old wisdom and new insights. Heart (British Cardiac Society). 2003;89(5):485–9.CrossRef
84.
85.
Kalbitz M, Schwarz S, Weber B, Bosch B, Pressmar J, et al. Cardiac depression in pigs after multiple trauma—characterization of posttraumatic structural and functional alterations. Sci Rep. 2017;7(1):17861.PubMedPubMedCentralCrossRef
86.
Kalbitz M, Pressmar J, Stecher J, Weber B, Weiss M, et al. The role of troponin in blunt cardiac injury after multiple trauma in humans. World J Surg. 2017;41(1):162–9.PubMedCrossRef
87.
Huber S, Biberthaler P, Delhey P, Trentzsch H, Winter H, et al. Predictors of poor outcomes after significant chest trauma in multiply injured patients: a retrospective analysis from the German Trauma Registry (Trauma Register DGU®). Scand J Trauma Resusc Emerg Med. 2014;22:52.PubMedPubMedCentralCrossRef
88.
Chistiakov DA, Orekhov AN, Bobryshev YV. Cardiac extracellular vesicles in normal and infarcted heart. Int J Mol Sci. 2016;17(1):63.PubMedCentralCrossRef
89.
Waldenström A, Gennebäck N, Hellman U, Ronquist G. Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS ONE. 2012;7(4):e34653.PubMedPubMedCentralCrossRef
90.
Malik ZA, Kott KS, Poe AJ, Kuo T, Chen L, et al. Cardiac myocyte exosomes: stability, HSP60, and proteomics. Am J Physiol Heart Circul Physiol. 2013;304(7):H954–65.CrossRef
91.
Yu X, Deng L, Wang D, Li N, Chen X, et al. Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: initiated by hypoxia inducible factor 1α, presented by exosomes. J Mol Cell Cardiol. 2012;53(6):848–57.PubMedCrossRef
92.
Gennebäck N, Hellman U, Malm L, Larsson G, Ronquist G, et al. Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes. J Extracel Vesicles. 2013;2:20167.CrossRef
93.
Liu Y, Liu Z, Xie Y, Zhao C, Xu J. Serum extracellular vesicles retard H9C2 cell senescence by suppressing miR-34a expression. J Cardiovasc Transl Res. 2019;12(1):45–50.PubMedCrossRef
94.
Tavakoli Dargani Z, Singla DK. Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Am J Physiol Heart Circul Physiol. 2019;317(2):H460–71.CrossRef
95.
Li C, Pei F, Zhu X, Duan DD, Zeng C. Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction. Clin Biochem. 2012;45(10–11):727–32.PubMedPubMedCentralCrossRef
96.
Xu C, Lu Y, Pan Z, Chu W, Luo X, et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci. 2007;120(Pt 17):3045–52.PubMedCrossRef
97.
98.
Castoldi G, Di Gioia CRT, Bombardi C, Catalucci D, Corradi B, et al. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. J Cell Physiol. 2012;227(2):850–6.PubMedCrossRef
99.
Li X, Wang J, Jia Z, Cui Q, Zhang C, et al. MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PLoS ONE. 2013;8(9):e74504.PubMedPubMedCentralCrossRef
100.
Izarra A, Moscoso I, Levent E, Cañón S, Cerrada I, et al. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Rep. 2014;3(6):1029–42.CrossRef
101.
Li S, Xiao F-Y, Shan P-R, Su L, Chen D-L, et al. Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2. J Hum Genet. 2015;60(11):709–16.PubMedCrossRef
102.
Nie H, Pan Y, Zhou Y. Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice. Biochem Biophys Res Commun. 2018;503(4):3174–9.PubMedCrossRef
103.
Yarana C, Carroll D, Chen J, Chaiswing L, Zhao Y, et al. Extracellular vesicles released by cardiomyocytes in a doxorubicin-induced cardiac injury mouse model contain protein biomarkers of early cardiac injury. Clin Cancer Res. 2018;24(7):1644–53.PubMedCrossRef
104.
Cheow ESH, Cheng WC, Lee CN, de Kleijn D, Sorokin V, et al. Plasma-derived extracellular vesicles contain predictive biomarkers and potential therapeutic targets for myocardial ischemic (MI) injury. Mol Cell Proteomics. 2016;15(8):2628–40.PubMedPubMedCentralCrossRef
105.
Börger V, Bremer M, Ferrer-Tur R, Gockeln L, Stambouli O, et al. Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents. Int J Mol Sci. 2017;18(7):1450.PubMedCentralCrossRef
106.
Bian S, Zhang L, Duan L, Wang X, Min Y, et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berlin, Germany). 2014;92(4):387–97.CrossRef
107.
Ma J, Zhao Y, Sun L, Sun X, Zhao X, et al. Exosomes derived from Akt-modified human umbilical cord mesenchymal stem cells improve cardiac regeneration and promote angiogenesis via activating platelet-derived growth factor D. Stem Cells Transl Med. 2017;6(1):51–9.PubMedCrossRef
108.
Zhao Y, Sun X, Cao W, Ma J, Sun L, et al. Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury. Stem Cells Int. 2015;2015:761643.PubMedPubMedCentralCrossRef
109.
Shao L, Zhang Y, Lan B, Wang J, Zhang Z, et al. MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair. Biomed Res Int. 2017;2017:4150705.PubMedPubMedCentralCrossRef
110.
Yu B, Kim HW, Gong M, Wang J, Millard RW, et al. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int J Cardiol. 2015;182:349–60.PubMedCrossRef
111.
Feng Y, Huang W, Wani M, Yu X, Ashraf M. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS ONE. 2014;9(2):e88685.PubMedPubMedCentralCrossRef
112.
Eworuke E, Major JM, Gilbert McClain LI. National incidence rates for Acute Respiratory Distress Syndrome (ARDS) and ARDS cause-specific factors in the United States (2006–2014). J Crit Care. 2018;47:192–7.PubMedCrossRef
113.
Bellani G, Laffey JG, Pham T, Fan E, Brochard L, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788–800.PubMedCrossRef
114.
Sun X, Singleton PA, Letsiou E, Zhao J, Belvitch P, et al. Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol. 2012;47(5):628–36.PubMedPubMedCentralCrossRef
115.
Letsiou E, Sammani S, Zhang W, Zhou T, Quijada H, et al. Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding. Am J Respir Cell Mol Biol. 2015;52(2):193–204.PubMedPubMedCentralCrossRef
116.
Shaver CM, Woods J, Clune JK, Grove BS, Wickersham NE, et al. Circulating microparticle levels are reduced in patients with ARDS. Crit Care (Lond, Engl). 2017;21(1):120.CrossRef
117.
Belizaire RM, Prakash PS, Richter JR, Robinson BR, Edwards MJ, et al. Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. J Am Coll Surg. 2012;214(4):648–55 (discussion 656-7).PubMedPubMedCentralCrossRef
118.
Neri T, Armani C, Pegoli A, Cordazzo C, Carmazzi Y, et al. Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. Eur Respir J. 2011;37(6):1494–502.PubMedCrossRef
119.
Shi Y, Luo P, Wang W, Horst K, Bläsius F, et al. M1 but not M0 extracellular vesicles induce polarization of RAW264.7 macrophages via the TLR4-NFκB pathway in vitro. Inflammation. 2020;43:1611–9.PubMedCrossRef
120.
Lee H, Zhang D, Wu J, Otterbein LE, Jin Y. Lung epithelial cell-derived microvesicles regulate macrophage migration via MicroRNA-17/221-induced integrin β(1) recycling. J Immunol (Baltimore, Md:1950). 2017;199(4):1453–64.CrossRef
121.
Wang L, Liu J, Xie W, Li G, Yao L, et al. miR-425 reduction causes aberrant proliferation and collagen synthesis through modulating TGF-β/Smad signaling in acute respiratory distress syndrome. Int J Clin Exp Pathol. 2019;12(7):2604–12.PubMedPubMedCentral
122.
Wu X, Wu C, Gu W, Ji H, Zhu L. Serum exosomal MicroRNAs predict acute respiratory distress syndrome events in patients with severe community-acquired pneumonia. Biomed Res Int. 2019;2019:3612020.PubMedPubMedCentralCrossRef
123.
Lee H, Zhang D, Zhu Z, Dela Cruz CS, Jin Y. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep. 2016;6:35250.PubMedPubMedCentralCrossRef
124.
Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer. Am J Respir Crit Care Med. 2017;196(10):1275–86.PubMedPubMedCentralCrossRef
125.
Rewa O, Bagshaw SM. Acute kidney injury-epidemiology, outcomes and economics. Nat Rev Nephrol. 2014;10(4):193–207.PubMedCrossRef
126.
Zeng X, McMahon GM, Brunelli SM, Bates DW, Waikar SS. Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol. 2014;9(1):12–20.PubMedCrossRef
127.
Thongboonkerd V. Roles for exosome in various kidney diseases and disorders. Front Pharmacol. 2019;10:1655.PubMedCrossRef
128.
Sonoda H, Yokota-Ikeda N, Oshikawa S, Kanno Y, Yoshinaga K, et al. Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2009;297(4):F1006–16.PubMedCrossRef
129.
Asvapromtada S, Sonoda H, Kinouchi M, Oshikawa S, Takahashi S, et al. Characterization of urinary exosomal release of aquaporin-1 and -2 after renal ischemia-reperfusion in rats. Am J Physiol Renal Physiol. 2018;314(4):F584–601.PubMedCrossRef
130.
Nielsen S, Frøkiaer J, Marples D, Kwon T-H, Agre P, et al. Aquaporins in the kidney: from molecules to medicine. Physiol Rev. 2002;82(1):205–44.PubMedCrossRef
131.
Sonoda H, Lee BR, Park K-H, Nihalani D, Yoon J-H, et al. miRNA profiling of urinary exosomes to assess the progression of acute kidney injury. Sci Rep. 2019;9(1):4692.PubMedPubMedCentralCrossRef
132.
Tőkés-Füzesi M, Woth G, Ernyey B, Vermes I, Mühl D, et al. Microparticles and acute renal dysfunction in septic patients. J Crit Care. 2013;28(2):141–7.PubMedCrossRef
133.
Delabranche X, Boisramé-Helms J, Asfar P, Berger A, Mootien Y, et al. Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy. Intensive Care Med. 2013;39(10):1695–703.PubMedCrossRef
134.
Soriano AO, Jy W, Chirinos JA, Valdivia MA, Velasquez HS, et al. Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med. 2005;33(11):2540–6.PubMedCrossRef
135.
Joop K, Berckmans RJ, Nieuwland R, Berkhout J, Romijn FP, et al. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost. 2001;85(5):810–20.PubMedCrossRef
136.
Du Cheyron D, Daubin C, Poggioli J, Ramakers M, Houillier P, et al. Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF. Am J Kidney Dis. 2003;42(3):497–506.PubMedCrossRef
137.
Zhou H, Pisitkun T, Aponte A, Yuen PST, Hoffert JD, et al. Exosomal Fetuin-A identified by proteomics. A novel urinary biomarker for detecting acute kidney injury. Kidney Int. 2006;70(10):1847–57.PubMedPubMedCentralCrossRef
138.
Chen H-H, Lai P-F, Lan Y-F, Cheng C-F, Zhong W-B, et al. Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion. J Cell Physiol. 2014;229(9):1202–11.PubMedCrossRef
139.
Panich T, Chancharoenthana W, Somparn P, Issara-Amphorn J, Hirankarn N, et al. Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury. BMC Nephrol. 2017;18(1):10.PubMedPubMedCentralCrossRef
140.
Lv L-L, Cao Y-H, Ni H-F, Xu M, Liu D, et al. MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis. Am J Physiol Renal Physiol. 2013;305(8):F1220–7.PubMedCrossRef
141.
Cavallari C, Dellepiane S, Fonsato V, Medica D, Marengo M, et al. Online hemodiafiltration inhibits inflammation-related endothelial dysfunction and vascular calcification of uremic patients modulating miR-223 expression in plasma extracellular vesicles. J Immunol (Baltimore, Md:1950). 2019;202(8):2372–83.CrossRef
142.
Xie JX, Fan X, Drummond CA, Majumder R, Xie Y, et al. MicroRNA profiling in kidney disease Plasma versus plasma-derived exosomes. Gene. 2017;627:1–8.PubMedPubMedCentralCrossRef
143.
Barutta F, Tricarico M, Corbelli A, Annaratone L, Pinach S, et al. Urinary exosomal microRNAs in incipient diabetic nephropathy. PLoS ONE. 2013;8(11):e73798.PubMedPubMedCentralCrossRef
144.
Ranghino A, Bruno S, Bussolati B, Moggio A, Dimuccio V, et al. The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury. Stem Cell Res Ther. 2017;8(1):24.PubMedPubMedCentralCrossRef
145.
Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol. 2009;20(5):1053–67.PubMedPubMedCentralCrossRef
146.
Reis LA, Borges FT, Simões MJ, Borges AA, Sinigaglia-Coimbra R, et al. Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats. PLoS ONE. 2012;7(9):e44092.PubMedPubMedCentralCrossRef
147.
Zhou Y, Xu H, Xu W, Wang B, Wu H, et al. Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res Ther. 2013;4(2):34.PubMedPubMedCentralCrossRef
148.
Bruno S, Grange C, Collino F, Deregibus MC, Cantaluppi V, et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS ONE. 2012;7(3):e33115.PubMedPubMedCentralCrossRef
149.
Collino F, Bruno S, Incarnato D, Dettori D, Neri F, et al. AKI Recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying MicroRNAs. J Am Soc Nephrol. 2015;26(10):2349–60.PubMedPubMedCentralCrossRef
150.
Kim WR, Flamm SL, Di Bisceglie AM, Bodenheimer HC. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology (Baltimore, MD). 2008;47(4):1363–70.CrossRef
151.
Royo F, Schlangen K, Palomo L, Gonzalez E, Conde-Vancells J, et al. Transcriptome of extracellular vesicles released by hepatocytes. PLoS ONE. 2013;8(7):e68693.PubMedPubMedCentralCrossRef
152.
Rodríguez-Suárez E, Gonzalez E, Hughes C, Conde-Vancells J, Rudella A, et al. Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity. J Proteomics. 2014;103:227–40.PubMedPubMedCentralCrossRef
153.
Masyuk AI, Masyuk TV, LaRusso NF. Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. J Hepatol. 2013;59(3):621–5.PubMedCrossRef
154.
Chen Y, Zeng Z, Shen X, Wu Z, Dong Y, et al. MicroRNA-146a-5p negatively regulates pro-inflammatory cytokine secretion and cell activation in lipopolysaccharide stimulated human hepatic stellate cells through inhibition of toll-like receptor 4 signaling pathways. Int J Mol Sci. 2016;17(7):1076.PubMedCentralCrossRef
155.
Witek RP, Yang L, Liu R, Jung Y, Omenetti A, et al. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009;136(1):320-330.e2.PubMedCrossRef
156.
Fonsato V, Collino F, Herrera MB, Cavallari C, Deregibus MC, et al. Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells (Dayton, Ohio). 2012;30(9):1985–98.CrossRef
157.
Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res. 2008;7(12):5157–66.PubMedPubMedCentralCrossRef
158.
Moratti E, Vezzalini M, Tomasello L, Giavarina D, Sorio C. Identification of protein tyrosine phosphatase receptor gamma extracellular domain (sPTPRG) as a natural soluble protein in plasma. PLoS ONE. 2015;10(3):e0119110.PubMedPubMedCentralCrossRef
159.
Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology (Baltimore, MD). 2012;56(5):1946–57.CrossRef
160.
Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, et al. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology (Baltimore, MD). 2017;65(2):475–90.CrossRef
161.
Kostallari E, Hirsova P, Prasnicka A, Verma VK, Yaqoob U, et al. Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2. Hepatology (Baltimore, MD). 2018;68(1):333–48.CrossRef
162.
Holman NS, Mosedale M, Wolf KK, LeCluyse EL, Watkins PB. Subtoxic alterations in hepatocyte-derived exosomes an early step in drug-induced liver injury? Toxicol Sci. 2016;151(2):365–75.PubMedPubMedCentralCrossRef
163.
Eguchi A, Franz N, Kobayashi Y, Iwasa M, Wagner N, et al. Circulating extracellular vesicles and their miR “Barcode” differentiate alcohol drinkers with liver injury and those without liver injury in severe trauma patients. Front Med. 2019;6:30.CrossRef
164.
Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. J Hepatol. 2016;64(1):60–8.PubMedCrossRef
165.
Chen L, Charrier A, Zhou Y, Chen R, Yu B, et al. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology (Baltimore, MD). 2014;59(3):1118–29.CrossRef
166.
Saha B, Momen-Heravi F, Furi I, Kodys K, Catalano D, et al. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90. Hepatology (Baltimore, MD). 2018;67(5):1986–2000.CrossRef
167.
Zhang Y-N, Poon W, Tavares AJ, McGilvray ID, Chan WCW. Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination. J Control Release. 2016;240:332–48.PubMedCrossRef
168.
Haga H, Yan IK, Takahashi K, Matsuda A, Patel T. Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice. Stem Cells Transl Med. 2017;6(4):1262–72.PubMedPubMedCentralCrossRef
169.
Tan CY, Lai RC, Wong W, Dan YY, Lim S-K, et al. Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models. Stem Cell Res Ther. 2014;5(3):76.PubMedPubMedCentralCrossRef
170.
Liu Y, Lou G, Li A, Zhang T, Qi J, et al. AMSC-derived exosomes alleviate lipopolysaccharide/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages. EBioMedicine. 2018;36:140–50.PubMedPubMedCentralCrossRef
171.
Zhao S, Liu Y, Pu Z. Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro. Drug Des Dev Ther. 2019;13:2887–97.CrossRef
172.
Hyun J, Wang S, Kim J, Kim GJ, Jung Y. MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells. Sci Rep. 2015;5:14135.PubMedPubMedCentralCrossRef
173.
Fröhlich M, Lefering R, Probst C, Paffrath T, Schneider MM, et al. Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the TraumaRegister DGU. J Trauma Acute Care Surg. 2014;76(4):921–7 (discussion 927-8).PubMedCrossRef
174.
Hildebrand F, Giannoudis PV, van Griensven M, Zelle B, Ulmer B, et al. Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries. Injury. 2005;36(2):293–302.PubMedCrossRef
175.
Qiao Z, Greven J, Horst K, Pfeifer R, Kobbe P, et al. Fracture healing and the underexposed role of extracellular vesicle-based cross talk. Shock (Augusta, Ga). 2018;49(5):486–96.CrossRef
176.
Ogura H, Kawasaki T, Tanaka H, Koh T, Tanaka R, et al. Activated platelets enhance microparticle formation and platelet-leukocyte interaction in severe trauma and sepsis. J Trauma. 2001;50(5):801–9.PubMedCrossRef
177.
Fujimi S, Ogura H, Tanaka H, Koh T, Hosotsubo H, et al. Increased production of leukocyte microparticles with enhanced expression of adhesion molecules from activated polymorphonuclear leukocytes in severely injured patients. J Trauma. 2003;54(1):114–9 (discussion 119-20).PubMedCrossRef
178.
Matijevic N, Wang Y-WW, Wade CE, Holcomb JB, Cotton BA, et al. Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. Thromb Res. 2014;134(3):652–8.PubMedPubMedCentralCrossRef
179.
Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, et al. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2018;84(2):245–56.PubMedPubMedCentralCrossRef
180.
Miyazawa B, Trivedi A, Togarrati PP, Potter D, Baimukanova G, et al. Regulation of endothelial cell permeability by platelet-derived extracellular vesicles. J Trauma Acute Care Surg. 2019;86(6):931–42.PubMedPubMedCentralCrossRef
181.
Lopez E, Srivastava AK, Burchfield J, Wang Y-W, Cardenas JC, et al. Platelet-derived- extracellular vesicles promote hemostasis and prevent the development of hemorrhagic shock. Sci Rep. 2019;9(1):17676.PubMedPubMedCentralCrossRef
182.
Mori MA, Ludwig RG, Garcia-Martin R, Brandão BB, Kahn CR. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–73.PubMedPubMedCentralCrossRef
183.
Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA. 2011;108(12):5003–8.PubMedPubMedCentralCrossRef
184.
Balusu S, van Wonterghem E, de Rycke R, Raemdonck K, Stremersch S, et al. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol Med. 2016;8(10):1162–83.PubMedPubMedCentralCrossRef
185.
Kumar A, Stoica BA, Loane DJ, Yang M, Abulwerdi G, et al. Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury. J Neuroinflamm. 2017;14(1):47.CrossRef
186.
Huang S, Ge X, Yu J, Han Z, Yin Z, et al. Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons. FASEB J. 2018;32(1):512–28.PubMedCrossRef
187.
Long X, Yao X, Jiang Q, Yang Y, He X, et al. Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflamm. 2020;17(1):89.CrossRef
188.
Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Investig. 2014;124(5):2136–46.PubMedPubMedCentralCrossRef
189.
Wang C, Zhang C, Liu L, A X, Chen B, , et al. Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury. Mol Ther. 2017;25(1):192–204.PubMedPubMedCentralCrossRef
190.
Zhu Z, Zhang D, Lee H, Menon AA, Wu J, et al. Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222. J Leukoc Biol. 2017;101(6):1349–59.PubMedPubMedCentralCrossRef
191.
Rontogianni S, Synadaki E, Li B, Liefaard MC, Lips EH, et al. Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. Commun Biol. 2019;2:325.PubMedPubMedCentralCrossRef
192.
Goetzl EJ, Yaffe K, Peltz CB, Ledreux A, Gorgens K, et al. Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins. FASEB J. 2020;34(2):3359–66.PubMedCrossRef
Metadata
Title
Extracellular vesicles as mediators and markers of acute organ injury: current concepts
Authors
Birte Weber
Niklas Franz
Ingo Marzi
Dirk Henrich
Liudmila Leppik
Publication date
03-02-2021
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 3/2022
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-021-01607-1

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