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Open Access 01-08-2021 | Rhabdomyosarcoma | Original Article

Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)

Authors: Fenja Albrecht, Heidi Wolters, Yvonne Ziert, Beate Timmermann, Rolf-Dieter Kortmann, Christiane Matuschek, Christian Rübe, Carmen Martini, Hans Christiansen, Hans Theodor Eich, Normann Willich, Diana Steinmann

Published in: Strahlentherapie und Onkologie | Issue 8/2021

Abstract

Purpose

The aim of the study is to evaluate treatment-related acute and late eye toxicity associated with radiation therapy in childhood and adolescence as correlated with RT (radiotherapy) doses.

Methods

From 2001 to 2016, a total of 1725 children and adolescents undergoing radiation therapy were prospectively documented in the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK). The RTOG/EORTC criteria were used to classify ocular acute and late effects. Uni- and multivariate analyses were carried out to evaluate the impact of patient age, pre-existing impairments, and radiation dose on ocular toxicity.

Results

Of all documented patients, 593 received dose to the eye and formed the basis of this analysis. In 435 patients, information on acute reaction was available and graded 1, 2, 3, and 4 in 49, 17, 0, and 2 patients, respectively. Information on late toxicity was available in 268 patients and graded 1, 2, 3, and 4 in 15, 11, 11, and 5 patients, respectively. The acute toxicity rate was significantly higher in children who received a maximum dose > 50 Gy to the eye (p < 0.001) and who had a pre-existing eye impairment (p < 0.001 in multivariate analysis). The development of late toxicity was significantly higher for patients experiencing acute toxicity and having received a radiation dose > 50 Gy.

Conclusion

Acute and late toxicity both correlate with high radiation dose to the eye (> 50 Gy) and acute toxicity additionally with pre-existing eye impairments.

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Title: Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)
Authors: Fenja Albrecht
Heidi Wolters
Yvonne Ziert
Beate Timmermann
Rolf-Dieter Kortmann
Christiane Matuschek
Christian Rübe
Carmen Martini
Hans Christiansen
Hans Theodor Eich
Normann Willich
Diana Steinmann
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Rhabdomyosarcoma
Radiotherapy
Published in: Strahlentherapie und Onkologie / Issue 8/2021
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-021-01793-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Evaluation of treatment-associated eye toxicity after irradiation in childhood and adolescence—results from the Registry of the Evaluation of Side Effects after Radiotherapy in Childhood and Adolescence (RiSK)

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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