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01-10-2021 | Keloid | Original Article

A hesitated approach: primary radiotherapy for keloids—a case series

Authors: Assis. Prof. Sezin Yuce Sari, M.D., Melek Tugce Yilmaz, M.D., Assoc. Prof. Gozde Yazici, M.D., Assoc. Prof. Hakan Uzun, M.D., Fazli Yagiz Yedekci, MSc, PhD, Prof. Gokhan Ozyigit, M.D.

Published in: Strahlentherapie und Onkologie | Issue 10/2021

Abstract

Purpose

To assess the efficacy and toxicity of hypofractionated radiotherapy (RT) alone in treatment-resistant symptomatic keloids.

Methods

Six patients with a total of 13 inoperable large keloid lesions and no response to previous treatments were admitted to our department between 2017 and 2019. All patients were examined for detailed wound localization, size, contour, and color assessment, and for objective and subjective symptoms. Response to treatment was graded as “complete remission” in case of full symptomatic relief and >75% decrease in lesion size, as “partial remission” in case of partial symptomatic relief and 25–75% decrease in lesion size, and as “stable disease” in case of no symptomatic relief or <25% decrease in lesion size. Patients were followed up monthly for the first 3 months and every 3 months thereafter by physical examination.

Results

A total dose of 37.5 Gy external RT in five fractions was prescribed by 6‑MeV electrons in 4 patients and 6‑MV photons in 2 patients. Complete response was obtained in all patients at the 6‑month control. All patients were satisfied with cosmetic results at their last control. Grade 2 dermatitis developed in all patients during the second week of RT but resolved completely in all after 6 months following the end of RT.

Conclusion

In keloids that are unresponsive to standard treatment, hypofractionated RT using a total dose of 37.5 Gy in five fractions is feasible.

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Title: A hesitated approach: primary radiotherapy for keloids—a case series
Authors: Assis. Prof. Sezin Yuce Sari, M.D.
Melek Tugce Yilmaz, M.D.
Assoc. Prof. Gozde Yazici, M.D.
Assoc. Prof. Hakan Uzun, M.D.
Fazli Yagiz Yedekci, MSc, PhD
Prof. Gokhan Ozyigit, M.D.
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keywords: Keloid
Radiotherapy
Published in: Strahlentherapie und Onkologie / Issue 10/2021
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-020-01736-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A hesitated approach: primary radiotherapy for keloids—a case series

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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