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01-10-2020 | Human Papillomavirus | Review Article

Radiomic biomarkers for head and neck squamous cell carcinoma

Authors: Stephanie Tanadini-Lang, Panagiotis Balermpas, Matthias Guckenberger, Matea Pavic, Oliver Riesterer, Diem Vuong, Marta Bogowicz

Published in: Strahlentherapie und Onkologie | Issue 10/2020

Abstract

Tumor heterogeneity is a well-known prognostic factor in head and neck squamous cell carcinoma (HNSCC). A major limitation of tissue- and blood-derived tumor markers is the lack of spatial resolution to image tumor heterogeneity. Tissue markers derived from tumor biopsies usually represent only a small tumor subregion at a single timepoint and are therefore often not representative of the tumors’ biology or the biological alterations during and after treatment. Similarly, liquid biopsies give an overall picture of the tumors’ secreted factors but completely lack any spatial resolution. Radiomics has the potential to give complete three-dimensional information about the tumor. We conducted a comprehensive literature search to assess the correlation of radiomics to tumor biology and treatment outcome in HNSCC and to assess current limitations of the radiomic biomarkers. In total, 25 studies that explored the ability of radiomics to predict tumor biology and phenotype in HNSCC and 28 studies that explored radiomics to predict post-treatment events were identified. Out of these 53 studies, only three failed to show a significant correlation. The major technical challenges are currently artifacts due to metal implants, non-standardized contrast injection, and delineation uncertainties. All studies to date were retrospective and none of the above-mentioned radiomics signatures have been validated in an independent cohort using an independent software implementation, which shows that transferability due to the numerous technical challenges is currently a major limitation. However, radiomics is a very young field and these studies hopefully pave the way for clinical implementation of radiomics for HNSCC in the future.

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Title: Radiomic biomarkers for head and neck squamous cell carcinoma
Authors: Stephanie Tanadini-Lang
Panagiotis Balermpas
Matthias Guckenberger
Matea Pavic
Oliver Riesterer
Diem Vuong
Marta Bogowicz
Publication date: 01-10-2020
Publisher: Springer Berlin Heidelberg
Keywords: Human Papillomavirus
Biomarkers
Published in: Strahlentherapie und Onkologie / Issue 10/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-020-01638-4

ACC 2024 Congress

Springer Medicine

Radiomic biomarkers for head and neck squamous cell carcinoma

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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