Top

Published in:

Open Access 01-07-2020 | Literatur kommentiert

Adjuvante Radiotherapie beim Niedrigrisikomammakarzinom: Langzeitergebnisse der ABCSG-8A-Studie

Authors: Dr. David Krug, PD Dr. Marciana-Nona Duma

Published in: Strahlentherapie und Onkologie | Issue 7/2020

Auszug

Der zusätzliche Nutzen der adjuvanten Radiotherapie bei Patientinnen mit Niedrigrisikomammakarzinom im Vergleich zu einer alleinigen endokrinen Therapie nach brusterhaltender Therapie in Bezug auf die Verhinderung eines Lokalrezidivs ist mehrfach belegt durch randomisiert-kontrollierte Studien. Langzeitdaten mit einer Nachbeobachtungszeit von >10 Jahren lagen bislang aber nur aus einer Studie vor. Die vorliegende Arbeit präsentiert nun die 10-Jahres-Daten der ABCSG-8A-Studie aus Österreich. …

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Darby S, McGale P et al (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378:1707–1716. https://doi.org/10.1016/S0140-6736(11)61629-2 CrossRef

Kunkler IH, Williams LJ, Jack WJL et al (2015) Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial. Lancet Oncol 16:266–273. https://doi.org/10.1016/S1470-2045(14)71221-5 CrossRefPubMed

Blamey RW, Bates T, Chetty U et al (2013) Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial. Eur J Cancer 49:1–9. https://doi.org/10.1016/j.ejca.2013.02.031 CrossRef

Fyles AW, McCready DR, Manchul LA et al (2004) Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 351:963–970. https://doi.org/10.1056/NEJMoa040595 CrossRefPubMed

Hughes KS, Schnaper LA, Bellon JR et al (2013) Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 31:2382–2387. https://doi.org/10.1200/JCO.2012.45.2615 CrossRefPubMedPubMedCentral

Pötter R, Gnant M, Kwasny W et al (2007) Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer. Int J Radiat Oncol Biol Phys 68:334–340. https://doi.org/10.1016/j.ijrobp.2006.12.045 CrossRefPubMed

Tinterri C, Gatzemeier W, Costa A et al (2013) Breast-conservative surgery with and without radiotherapy in patients aged 55–75 years with early-stage breast cancer: a prospective, randomized, multicenter trial analysis after 108 months of median follow-up. Ann Surg Oncol 21:408–415. https://doi.org/10.1245/s10434-013-3233-x CrossRefPubMed

Matuschek C, Bölke E, Haussmann J et al (2017) The benefit of adjuvant radiotherapy after breast conserving surgery in older patients with low risk breast cancer—a meta-analysis of randomized trials. Radiat Oncol 12:60–68. https://doi.org/10.1186/s13014-017-0796-x CrossRefPubMedPubMedCentral

Homepage des Bundesinstituts für Bevölkerungsforschung. https://www.bib.bund.de/Permalink.html?id=10262290. Zugegriffen: 20. Febr. 2020

10.

Borm KJ, Oechsner M, Düsberg M et al (2020) Irradiation of regional lymph node areas in breast cancer—dose evaluation according to the Z0011, AMAROS, EORTC 10981-22023 and MA-20 field design. Radiother Oncol 142:195–201. https://doi.org/10.1016/j.radonc.2019.08.021 CrossRefPubMed

Title: Adjuvante Radiotherapie beim Niedrigrisikomammakarzinom: Langzeitergebnisse der ABCSG-8A-Studie
Authors: Dr. David Krug
PD Dr. Marciana-Nona Duma
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 7/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-020-01617-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Adjuvante Radiotherapie beim Niedrigrisikomammakarzinom: Langzeitergebnisse der ABCSG-8A-Studie

Auszug

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Auszug

Please log in to get access to this content

Other articles of this Issue 7/2020

Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer+

Linac-based stereotactic body radiation therapy for low and intermediate-risk prostate cancer

Treatment strategies to prevent and reduce gynecomastia and/or breast pain caused by antiandrogen therapy for prostate cancer

PSMA-positive nodal recurrence in prostate cancer

Moderately HRT vs. CRT for localized prostate cancer using image-guided VMAT with SIB: evaluation of acute and late toxicities

An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report