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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 1/2020

01-01-2020 | Literatur kommentiert

Pravastatin kann strahleninduzierte Fibrosen im Kopf-Hals-Bereich reduzieren

Author: Prof. Dr. med. Thomas B. Brunner

Published in: Strahlentherapie und Onkologie | Issue 1/2020

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PRAVACUR, eine Phase-II-Studie, untersuchte die Wirksamkeit von Pravastatin als antifibrotisches Medikament bei Patienten mit manifester kutaner und/oder subkutaner Fibrose nach einer komplettierten Strahlentherapie oder Radiochemotherapie [3]. …
Literature
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2.
Gresser U, Gathof BS (2004) Atorvastatin: gold standard for prophylaxis of myocardial ischemia and stroke—comparison of the clinical benefit of statins on the basis of randomized controlled endpoint studies. Eur J Med Res 9(1):1–17 (Review. PubMed PMID: 14766335)PubMed
3.
Haydont V, Bourgier C, Pocard M, Lusinchi A, Aigueperse J, Mathé D, Bourhis J, Vozenin-Brotons MC (2007) Pravastatin Inhibits the Rho/CCN2/extracellular matrixcascade in human fibrosis explants and improves radiation-induced intestinalfibrosis in rats. Clin Cancer Res 13(18 Pt 1):5331–5340 (PubMed PMID: 17875761)CrossRef
4.
Metadata
Title
Pravastatin kann strahleninduzierte Fibrosen im Kopf-Hals-Bereich reduzieren
Author
Prof. Dr. med. Thomas B. Brunner
Publication date
01-01-2020
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 1/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-019-01544-4

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