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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 9/2018

01-09-2018 | Original Article

Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention

Authors: S. Janssen, D. Rades, A. Meyer, F. B. Fahlbusch, I. Wildfang, A. Meier, S. Schild, H. Christiansen, C. Henkenberens

Published in: Strahlentherapie und Onkologie | Issue 9/2018

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Abstract

Purpose

To assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a second breast-conserving therapy or following mastectomy.

Methods

Between 03/2004 and 10/2016, 83 breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45 Gy (1.8 Gy per fraction) administered either to the partial breast (n = 42) or mastectomy scar (n = 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and breast-cancer specific) were evaluated by univariate and multivariate analyses.

Results

The median follow-up was 35 months (range 3–143 months). The median time interval between the first irradiation and re-RT was 117 months (range 16–357 months). The prognostic factors for favorable overall survival rates were younger age (p = 0.045), lower T‑category (p = 0.019), and N0 category (p = 0.005). N0 was also superior to N+ with respect to outfield recurrences (p = <0.001) and breast cancer-specific survival (p = 0.025). Acute and late skin toxicity was generally low (<grade 3).

Conclusion

Re-RT with 45 Gy (1.8 Gy per fraction) for partial breast or mastectomy scar after the second surgery resulted in high local control rates and tolerable skin toxicity.
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Metadata
Title
Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention
Authors
S. Janssen
D. Rades
A. Meyer
F. B. Fahlbusch
I. Wildfang
A. Meier
S. Schild
H. Christiansen
C. Henkenberens
Publication date
01-09-2018
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 9/2018
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-018-1315-1

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