Top

Strahlentherapie und Onkologie

Published in:

01-07-2017 | Literatur kommentiert

Konsolidierende Lokaltherapie verbessert progressionsfreies Überleben von Patienten mit oligometastasiertem NSCLC

Ergebnisse einer randomisierten Phase-II-Studie

Authors: Dr. med. Tobias Finazzi, Prof. Dr. med. Matthias Guckenberger

Published in: Strahlentherapie und Onkologie | Issue 7/2017

Auszug

Gomez und Mitarbeiter untersuchten in einer prospektiv randomisierten, multizentrischen Phase-II-Studie den Nutzen einer konsolidierenden Lokaltherapie nach Erstlinientherapie bei Patienten mit oligometastasierten, nicht-kleinzelligen Lungenkarzinomen (NSCLC). …

Gomez DR, Blumenschein GR Jr., Lee JJ et al (2016) Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: A multicentre, randomised, controlled, phase 2 study. Lancet Oncol 17:1672–1682CrossRefPubMed

De Ruysscher D, Wanders R, van Baardwijk A et al (2012) Radical treatment of non-small-cell lung cancer patients with synchronous oligometastases: Long-term results of a prospective phase II trial (nct01282450). J Thorac Oncol 7:1547–1555CrossRefPubMed

Downey RJ, Ng KK, Kris MG et al (2002) A phase II trial of chemotherapy and surgery for non-small cell lung cancer patients with a synchronous solitary metastasis. Lung Cancer 38:193–197CrossRefPubMed

Iyengar P, Kavanagh BD, Wardak Z et al (2014) Phase II trial of stereotactic body radiation therapy combined with erlotinib for patients with limited but progressive metastatic non-small-cell lung cancer. J Clin Oncol 32:3824–3830CrossRefPubMed

Rusthoven CG, Yeh N, Gaspar LE (2015) Radiation therapy for oligometastatic non-small cell lung cancer: Theory and practice. Cancer J 21:404–412CrossRefPubMed

Lussier YA, Khodarev NN, Regan K et al (2012) Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific micrornas. PLOS ONE 7:e50141CrossRefPubMedPubMedCentral

Widder J, Klinkenberg TJ, Ubbels JF et al (2013) Pulmonary oligometastases: Metastasectomy or stereotactic ablative radiotherapy? Radiother Oncol 107:409–413CrossRefPubMed

Ashworth AB, Senan S, Palma DA et al (2014) An individual patient data metaanalysis of outcomes and prognostic factors after treatment of oligometastatic non-small-cell lung cancer. Clin Lung Cancer 15:346–355CrossRefPubMed

Rieber J, Abbassi-Senger N, Adebahr S et al (2016) Influence of institutional experience and technological advances on outcome of stereotactic body radiation therapy for oligometastatic lung disease. Int J Radiat Oncol Biol Phys. doi:10.1016/j.ijrobp.2016.09.026 PubMed

10.

Congedo MT, Cesario A, Lococo F et al (2012) Surgery for oligometastatic non-small cell lung cancer: Long-term results from a single center experience. J Thorac Cardiovasc Surg 144:444–452CrossRefPubMed

11.

Andrews DW, Scott CB, Sperduto PW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the rtog 9508 randomised trial. Lancet 363:1665–1672CrossRefPubMed

12.

Lewis SL, Porceddu S, Nakamura N et al (2015) Definitive stereotactic body radiotherapy (SBRT) for extracranial oligometastases: An international survey of >1000 radiation oncologists. Am J Clin Oncol. doi:10.1097/coc.0000000000000169 PubMed

Title: Konsolidierende Lokaltherapie verbessert progressionsfreies Überleben von Patienten mit oligometastasiertem NSCLC
Ergebnisse einer randomisierten Phase-II-Studie
Authors: Dr. med. Tobias Finazzi
Prof. Dr. med. Matthias Guckenberger
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 7/2017
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-017-1147-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Konsolidierende Lokaltherapie verbessert progressionsfreies Überleben von Patienten mit oligometastasiertem NSCLC

Ergebnisse einer randomisierten Phase-II-Studie

Auszug

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Auszug

Please log in to get access to this content

Other articles of this Issue 7/2017

General health status of long-term cervical cancer survivors after radiotherapy

Reirradiation for recurrent head and neck cancers using charged particle or photon radiotherapy

Patient-reported symptoms during radiotherapy

Salvage-Radiotherapie mit antiandrogener Therapie nach Prostatektomie

Spinal cord constraints in the era of high-precision radiotherapy

Small bowel protection in IMRT for rectal cancer