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Strahlentherapie und Onkologie

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Open Access 01-06-2017 | Original Article

Early inflammatory changes in radiation-induced oral mucositis

Effect of pentoxifylline in a mouse model

Authors: Sylvia Gruber, Eva Bozsaky, Eva Roitinger, Karoline Schwarz, Margret Schmidt, Wolfgang Dörr

Published in: Strahlentherapie und Onkologie | Issue 6/2017

Abstract

Purpose

Early inflammation is a major factor of mucosal reactions to radiotherapy. Pentoxifylline administration resulted in a significant amelioration of radiation-induced oral mucositis in the mouse tongue model. The underlying mechanisms may be related to the immunomodulatory properties of the drug. The present study hence focuses on the manifestation of early inflammatory changes in mouse tongue during daily fractionated irradiation and their potential modulation by pentoxifylline.

Materials and methods

Daily fractionated irradiation with 5 fractions of 3 Gy/week (days 0–4, 7–11) was given to the snouts of mice. Groups of 3 animals per day were euthanized every second day between day 0 and 14. Pentoxifylline (15 mg/kg, s. c.) was administered daily from day 5 to the day before sacrifice. The expression of the inflammatory proteins TNFα, NF-κB, and IL-1β were analysed.

Results

Fractionated irradiation increased the expression of all inflammatory markers. Pentoxifylline significantly reduced the expression of TNFα and IL-1β, but not NF-κB.

Conclusion

Early inflammation, as indicated by the expression of the inflammatory markers TNFα, NF-κB, and IL-1β, is an essential component of early radiogenic oral mucositis. Pentoxifylline differentially modulated the expression of different inflammatory markers. The mucoprotective effect of pentoxifylline does not appear to be based on modulation of NF-κB-associated inflammation.

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Title: Early inflammatory changes in radiation-induced oral mucositis
Effect of pentoxifylline in a mouse model
Authors: Sylvia Gruber
Eva Bozsaky
Eva Roitinger
Karoline Schwarz
Margret Schmidt
Wolfgang Dörr
Publication date: 01-06-2017
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 6/2017
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-017-1119-8

At a glance: The STEP trials

Springer Medicine

Early inflammatory changes in radiation-induced oral mucositis

Effect of pentoxifylline in a mouse model

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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