Top

Published in:

01-02-2016 | Literatur kommentiert

Keine Verbesserung des progressionsfreien Überlebens von Patienten mit lokal fortgeschrittenem NSCLC durch konsolidierende Chemotherapie nach simultaner Radiochemotherapie

Authors: Dr. med. Nadja Ebert, Prof. Dr. Michael Baumann

Published in: Strahlentherapie und Onkologie | Issue 2/2016

Auszug

Ahn JS, Ahn YC, Kim JH et al (2015) Multinational randomized phase III trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable stage III non-small-cell lung cancer. KCSG-LU05-04. J Clin Oncol 33:2660–2666 …

Zatloukal P, Petruzelka L, Zemanova M, Havel L, Janku F, Judas L, Kubik A, Krepela E, Fiala P, Pecen L (2004) Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study. Lung Cancer 46:87–98PubMedCrossRef

Curran WJ, Paulus R, Langer CJ, Komaki R, Lee JS, Hauser S, Movsas B, Wasserman T, Rosenthal SA, Gore E, Machtay M, Sause W, Cox JD (2011) Sequential vs concurrent chemoradiation for stage III non–small cell lung cancer: randomized phase iii trial RTOG 9410. J Natl Cancer Inst 103:1452–1460PubMedPubMedCentralCrossRef

Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat M-C, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon J-P (2010) Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non–small-cell lung cancer. J Clin Oncol 28:2181–2190PubMedCrossRef

Belani CP, Choy H, Bonomi P, Scott C, Travis P, Haluschak J, Curran WJ (2005) combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non–small-cell lung cancer: a randomized phase II locally advanced multi-modality protocol. J Clin Oncol 23:5883–5891PubMedCrossRef

Ahn JS, Ahn YC, Kim J-H, Lee CG, Cho EK, Lee KC, Chen M, Kim D-W, Kim H-K, Min YJ, Kang J-H, Choi J-H, Kim S-W, Zhu G, Wu Y-L, Kim SR, Lee KH, Song HS, Choi Y-L, Sun J-M, Jung S-H, Ahn M-J, Park K (2015) Multinational randomized phase III trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable stage III non-small-cell lung cancer: KCSG-LU05-04. J Clin Oncol 33:2660–2666PubMedCrossRef

Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran WJ, Choy H (2015) Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol 16:187–199PubMedCrossRef

Auperin A, Le Pechoux C, Pignon JP, Koning C, Jeremic B, Clamon G, Einhorn L, Ball D, Trovo MG, Groen HJM, Bonner JA, Le Chevalier T, Arriagada R (2006) Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (NSCLC): a meta-analysis of individual data from 1764 patients. Ann Oncol 17:473–483PubMedCrossRef

Pignon J-P, le Maître A, Bourhis J (V) Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update. Int J Radiat Oncol Biol Phys 69:S112–S114

Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration (2008) Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol 26:5802–5812PubMedCentralCrossRef

10.

Gandara DR, Chansky K, Albain KS, Leigh BR, Gaspar LE, Lara PN, Burris H, Gumerlock P, Kuebler JP, Bearden JD, Crowley J, Livingston R (2003) Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non–small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J Clin Oncol 21:2004–2010PubMedCrossRef

11.

Hanna N, Neubauer M, Yiannoutsos C, McGarry R, Arseneau J, Ansari R, Reynolds C, Govindan R, Melnyk A, Fisher W, Richards D, Bruetman D, Anderson T, Chowhan N, Nattam S, Mantravadi P, Johnson C, Breen T, White A, Einhorn L (2008) Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non–small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. J Clin Oncol 26:5755–5760PubMedCrossRef

12.

Jain AK, Hughes RS, Sandler AB, Dowlati A, Schwartzberg LS, Dobbs T, Schlabach L, Wu J, Muldowney NJ, Choy H (2009) A phase II study of concurrent chemoradiation with weekly docetaxel, carboplatin, and radiation therapy followed by consolidation chemotherapy with docetaxel and carboplatin for locally advanced inoperable non-small cell lung cancer (NSCLC). J Thorac Oncol 4:722–727PubMedCrossRef

13.

Lee KC, Lee SH, Lee Y, Park SH, Park J, Cho EK, Shin DB, Lee JH, Kim DY, Kim ST (2008) Prospective pilot study of consolidation chemotherapy with docetaxel and cisplatin after concurrent chemoradiotherapy for advanced head and neck cancer. Int J Radiat Oncol Biol Phys 71:187–191PubMedCrossRef

14.

Tsujino K, Kurata T, Yamamoto S, Kawaguchi T, Kubo A, Isa S, Hasegawa Y, Ou SH, Takada M, Ando M (2013) Is consolidation chemotherapy after concurrent chemo-radiotherapy beneficial for patients with locally advanced non-small-cell lung cancer? A pooled analysis of the literature. J Thorac Oncol 8:1181–1189PubMedCrossRef

15.

NSCLC Meta-analyses Collaborative Group (2010) Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data. Lancet 375:1267–1277PubMedCentralCrossRef

Title: Keine Verbesserung des progressionsfreien Überlebens von Patienten mit lokal fortgeschrittenem NSCLC durch konsolidierende Chemotherapie nach simultaner Radiochemotherapie
Authors: Dr. med. Nadja Ebert
Prof. Dr. Michael Baumann
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2016
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0933-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Keine Verbesserung des progressionsfreien Überlebens von Patienten mit lokal fortgeschrittenem NSCLC durch konsolidierende Chemotherapie nach simultaner Radiochemotherapie

Auszug

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Auszug

Please log in to get access to this content

Other articles of this Issue 2/2016

Prognosebestimmung mit Genexpressionsanalysen

Image-guided intensity-modulated radiotherapy of prostate cancer

Verbesserte Prognose für symptomfreie ältere Frauen mit einem durch Mammographie detektiertem Mammakarzinom?

Tomotherapy PET-guided dose escalation

Scanned ion beam therapy for prostate carcinoma

Cone-beam CT-guided radiotherapy in the management of lung cancer