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01-02-2016 | Original Article

Scanned ion beam therapy for prostate carcinoma

Comparison of single plan treatment and daily plan-adapted treatment

Authors: Dipl.-Ing.(FH) Sebastian Hild, Dr.-Ing. Christian Graeff, Dr.sc.hum. Antoni Rucinski, Prof. Dr.rer.nat. Klemens Zink, Dr. med. Gregor Habl, Prof. Marco Durante, Ph. D., Prof. Dr. med. Klaus Herfarth, Prof. Dr.rer.nat. Christoph Bert

Published in: Strahlentherapie und Onkologie | Issue 2/2016

Abstract

Background and purpose

Intensity-modulated particle therapy (IMPT) for tumors showing interfraction motion is a topic of current research. The purpose of this work is to compare three treatment strategies for IMPT to determine potential advantages and disadvantages of ion prostate cancer therapy.

Materials and methods

Simulations for three treatment strategies, conventional one-plan radiotherapy (ConvRT), image-guided radiotherapy (IGRT), and online adaptive radiotherapy (ART) were performed employing a dataset of 10 prostate cancer patients with six CT scans taken at one week intervals. The simulation results, using a geometric margin concept (7–2 mm) as well as patient-specific internal target volume definitions for IMPT were analyzed by target coverage and exposure of critical structures on single fraction dose distributions.

Results

All strategies led to clinically acceptable target coverage in patients exhibiting small prostate motion (mean displacement < 4 mm), but IGRT and especially ART led to significant sparing of the rectum. In 20 % of the patients, prostate motion exceeded 4 mm causing insufficient target coverage for ConvRT (V95_mean = 0.86, range 0.63–0.99) and IGRT (V95_mean = 0.91, range 0.68–1.00), while ART maintained acceptable target coverage.

Conclusion

IMPT of prostate cancer demands consideration of rectal sparing and adaptive treatment replanning for patients exhibiting large prostate motion.

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Title: Scanned ion beam therapy for prostate carcinoma
Comparison of single plan treatment and daily plan-adapted treatment
Authors: Dipl.-Ing.(FH) Sebastian Hild
Dr.-Ing. Christian Graeff
Dr.sc.hum. Antoni Rucinski
Prof. Dr.rer.nat. Klemens Zink
Dr. med. Gregor Habl
Prof. Marco Durante, Ph. D.
Prof. Dr. med. Klaus Herfarth
Prof. Dr.rer.nat. Christoph Bert
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2016
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0925-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Scanned ion beam therapy for prostate carcinoma

Comparison of single plan treatment and daily plan-adapted treatment

Abstract

Background and purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and purpose

Materials and methods

Results

Conclusion

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